Clonidine- An ideal premedicant for attenuation of haemodynamic side effects of intravenous Ketamine anaesthesia
Journal Title: Medpulse International Journal of Anesthesiology - Year 2018, Vol 8, Issue 2
Abstract
Background: Using Ketamine as an anaesthetic agent is often associated with tachycardia and hypertension due to cardiostimulatory effects. Clonidine being an α2 agonist is supposed to be an ideal premedicant for it. Materials and methods:The study was carried out on 75 patients of either sex, age group 15-45 years and ASA Grade I or II physical status, posted for surgery under general anaesthesia of duration approximalely 30-40 minutes. Patients were divided into 3 equal groups. Group A received tab Diazepam 10mg while group B and group C received 0.2mg and 0.3mg tabs of oral Clonidine 90 min before induction of anaesthetia with intravenous ketamine. They were analysed for hemodynamic parameters at 1,3,5,8 and 10min postinduction, preinduction sedation level, total dose of ketamine required and postoperative emergence.Results: Group C had significantly higher sedation score compared to group A and B in perinduction period 90min after premedication. After induction in case of heart rate(HR) and mean arterial blood pressure(MAP), there was significant increase from baseline for 3 minutes in group A and significant decrease throughout the monitoring period in group C while they were stable without any significant changes throughout the study period in group B. Total dose of ketamine was significantly reduced in group B and C compared to group A. Out of 25, no. of patients having postoperative emergence were 5,4 and 6 respectively in group A,B and C.Conclusion: Thus from our study it could be inferred that tab. Clonidine is a better premedication than tab. diazepam for Ketamine anaesthesia and between the 2 doses of clonidine, tab clonidine 0.2 mg is better as it gives all the advantages but avoids the excess fall in HR and MAP as seen in tab. clonidine 0.3 mg.
Authors and Affiliations
Sheetal SJayakar, Surekha S Shinde
Keywords
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- EP ID EP449593
- DOI 10.26611/1015826
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