A comparative study of dexmedetomidine versus lignocaine used for laryngoscopy and endotracheal intubation with respect to heart rate at tertiary health care centre
Journal Title: Medpulse International Journal of Anesthesiology - Year 2019, Vol 10, Issue 1
Abstract
Background: Direct laryngoscopy and endotracheal intubation following induction of anesthesia is almost always associated with hemodynamic changes due to reflex sympathetic discharge. This increased sympatho adrenal activity may result in hypertension, tachycardia, and arrhythmias. Aims and Objectives: To study of Dexmedetomidine versus lignocaine used for laryngoscopy and endotracheal intubation with respect to heart rate at tertiary health care centre. Methodology: This was prospective randomized single blind control study carried out in the department of Anesthesia of MIMSR medical college, Latur during the two year period i.e. September 2013 to September 2015 in 80 patients. The patients were divided into Group L- patients receiving i.v. 2 % 1.5 ml/kg lignocaine (preservative free) 3 minute before laryngoscopy. Group D- Patients receiving i.v. dexmedetomide (0.6mcg/kg) 10 minutes before laryngoscopy. The statistical analysis was done by unpaired t-test and calculated by SPSS 19 version. Result : The base line HR was comparable in both the group i.e. Heart rate (beats per minute) -85.88±S6.45 and 85.98± 6.96( t=0.06 ; 0.95,NS) ; Immediately after induction the HR was 85.05± 13.76 and 86.03±7.33(t= 0.40; 0.69,NS); During intubation (0 minute)- 91.78±5.43 and 92.18±7.25 (t=0.28; p>0.78,NS); 1 minute post intubation was 88.2 ± 6.26 and 91.85±7.92 (t=2.28; p<0.02,S); 2 minute post intubation was 86.48 ± 6.07 and 89.73±7.88 (t=2.06; p<0.04,S); 3 minute post intubation was 83.83±5.82 and 87.2±8.13(t=2.13,P<0.04,S); 4 minute post intubation was 81.38±6.04 and 84.53±7.96(t=1.99,0.04,S); 5 minute post intubation was 79.85±6.16 and 82.60±7.78 (t=1.75; 0.08,S); 10 minute post intubation was 78.38±5.90 and 80.53±7.79 (t=1.39, p>0.17,NS) respectively in the Dexmedetomide group and Lignocaine Group . Conclusion: it can be conclude from our study that intravenous dexmedetomide is more effective in attenuating the HR response to intubation than intravenous lignocaine.
Authors and Affiliations
Bhagwan Marotirao Patil, P K Jadhav
Keywords
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- EP ID EP589646
- DOI 10.26611/101510113
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