CO, Pb++ and SO2 effects on L-type calcium channel and action potential in human atrial myocytes. In silico study
Journal Title: TecnoLógicas - Year 2017, Vol 20, Issue 40
Abstract
Exposure to air pollutants like carbon monoxide (CO), lead (Pb++) and sulfur dioxide (SO2) promotes the occurrence of cardiovascular diseases. Experimental studies have shown that CO, Pb++and SO2block L-type calcium channels, reducing the calcium current (ICaL) and the action potential duration (APD), which favors the initiation of atrial arrhythmias. The goal is to study the effects of CO, Pb++and SO2at different concentrations on ICaLand action potential using computational simulation. For this purpose, models of the effects of the air pollutants on the atrial L-type calcium channel were developed and were incorporatedinto a mathematical model of a human atrial cell. The results suggest thatCO, Pb++and SO2block the ICaLcurrent in a fraction that increases along with the concentration, generating an APD shortening. These results are consistent with experimental studies. The combined effect of the three air pollutants produced an APD shortening, which is considered to be a pro-arrhythmic effect.
Authors and Affiliations
Diana C. Pachajoa, Catalina Tobón, Juan P. Ugarte, Javier Saiz
The use of an industrial mineral waste as catalyst in the hydroconversion of dibenzylether and a colombian subbituminous coal
An industrial mineral waste produced in the aluminum sulphate industry was selected as a low cost catalyst precursor. This material has been active in dibenzylether hydroconversion, as a model compound of C-O linkages in...
Design and construction of a hybrid system of heating air by combustion of biomass and solar radiation, using phase change material (PCM) as a source of thermal storage, for cassava drying
This study consisted of designing, building and validation a hybrid system of heating air by combustion of biomass and solar radiation, using phase change material (PCM) as a thermal storage source, for cassava dry...
Development and implementation of technologies for physical telerehabilitation in Latin America: a systematic review of literature, programs and projects
Telerehabilitation has arised by the inclusion of emerging technologies for capturing, transmitting, analyzing and visualizing movement patterns associated to musculoskeletal disorders. This therapeuti...
Automatic classification of vowels in Colombian sign language
Sign language recognition is a highly-complex problem due to the amount of static and dynamic gestures needed to represent such language, especially when it changes from country to country. This article focuses on static...
Methodology for determining angular displacement in three-phase transformers
This paper presents methodology for determining angular displacement (connections or vector group (colloquial)) in three-phase transformers. The proposed methodology is useful to determin...