Coenzyme Q10 - A Review of Its Promise
Journal Title: IOSR Journal of Pharmacy and Biological Sciences (IOSR-JPBS) - Year 2016, Vol 11, Issue 3
Abstract
Coenzyme Q10 (CoQ10) is a powerful antioxidant found in the membranes of many organelles. Experimental studies in animal models suggest that CoQ10 may protect against neuronal damage that is caused by ischemia, atherosclerosis and toxic injury. It buffers the potential adverse consequences of free radicals produced during oxidative phosphorylation in the inner mitochondrial membrane. Oxidative stress, resulting in glutathione loss and oxidative DNA and protein damage, has been involved in many neurodegenerative disorders, including Alzheimer's disease, Parkinson's disease, and Huntington's disease. Though most preliminary clinical trials showing that CoQ10 may offer promise in many brain disorders. Available data suggests that oral CoQ10 seems to be relatively safe and tolerated across the range of 300–2,400 mg/day. This, antioxidant has potential for use in prevention and treatment of cardiovascular disease, particularly hypertension, hyperlipidemia, coronary artery disease, heart failure, diabetes and cancer. This article focuses on the action of Coenzyme Q10 and its uses.
Authors and Affiliations
S. Arshiya Banu1, S. Asadulla2, M. Venkata Subbaiah 3
Keywords
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