Coenzyme Q10 Effect on Varicocele Associated Asthenozoospermia
Journal Title: IOSR Journal of Pharmacy and Biological Sciences (IOSR-JPBS) - Year 2016, Vol 11, Issue 2
Abstract
Back Ground: Varicocele It Is One Of The Leading Causes Of Male Infertility. Although 15% Of Adult Men Are Believed To Have Either Clinical Or Subclinical Varicocele, Its Prevalence May Be As High As 40% Among Infertile Men. Subfertile Men With Varicocele Have Disrupted Spermatogenesis, Which Is Manifested By Low Sperm Count, Decreased Sperm Motility, And A Low Percentage Of Normal Sperm Morphology. By Providing Readily Available Energy For Use By Spermatozoa Thus Positively Affecting Sperm Motility, Maturation And The Spermatogenic Process, A Key Role In Sperm Metabolism Is Strongly Suggested By The High Levels Of Coenzyme Q10 In Epididymal Lumen And Sperm Cells. Objective: Placebo-Controlled, Double-Blind Randomized Trial Assigned To Determine The Efficacy Of Coenzyme Q10 Supplementation On Sperm Motility In Varicocele Patients . Patients And Methods: A Total Of 52 Infertile Men With Varicocele Associated Asthenozoospermia ( Progressive Motile Sperm ≤ 32% Within 60 Minutes) ( WHO 2010) Were Randomly Assigned To Receive 200 Mg Coenzyme Q10 (Naturs Bounty, ING-USA) Orally Daily (27 In Group 1) Or A Similar Placebo Regimen (25 In Group 2) During A 6 Months Period. Monthly Follow Up By Semen Analysis Was Done. Main Outcome Measure: Variations In Sperm Kinetic Parameters Used For Patient Selection Results: Spermatozoa Motility Increased Significantly After Treatment, From 8.08±0.27 To 40.56±4.49 P= <0.001. Conclusion: The Exogenous Administration Of Coenzyme Q10 Is Effective In Improving Sperm Kinetic Features In Patients Affected By Varicocele Asthenozoospermia.
Authors and Affiliations
Huda I. Al-Qadhi, Haidar M. Jawad, Usama S. Al-Nasiri 3
Keywords
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