The Effect of Steroidal Extract of Nerium oleander on the Liver Tissue Structure of Albino Mice
Journal Title: IOSR Journal of Pharmacy and Biological Sciences (IOSR-JPBS) - Year 2017, Vol 12, Issue 2
Abstract
Nerium oleander is an evergreen shrub of Apocynaceae family cultivated worldwide as an ornamental plant. All parts of the plant are toxic and contain a mixture of very toxic cardiac glycosides of cardenolides. albino mice were divided into four groups. group I was normal control group; and others represented three concentration from steroid component of Nerium oleander (0.003,0.006 and 0.012 mg/kg). Liver marker enzymes were assayed in serum. Levels of marker enzymes such as alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were increased significantly. Sections of livers were observed under microscope for the histopathological changes such as destruction of the liver architecture with increased inflammation was observed compared with control.
Authors and Affiliations
Sahar A. A. Malik Al-Saadi, Karim H. Al- Derawi, Shiama Abd Alrasool
Keywords
Related Articles
- EP ID EP388392
- DOI 10.9790/3008-1202015255
- Views 60
- Downloads 0
GC and GC-MS analysis of the dried Leaf and Rhizome essential oil of Curcuma aurantiaca Zijp. (Zingiberaceae).
The chemical investigation on volatile oil obtained by hydrodistillation of air dried leaves and rhizome of Curcuma aurantiaca Zijp. (Zingiberaceae) from Southern india done by GC and GC-MS. The major constituents of the...
Detection of Some Biomarkers in Iraqi Patients with Thyroid Carcinoma
Background:Thyroid cancer, the most common endocrine malignancy, has increased dramatically in the lastyears.Cathepsin D and Galectin-3 have been implicated in the regulation of cellular growth, differentiation and malig...
Profile of Heavy Metals in Crude Oil Commonly Consumed For Medicinal Purposes in Abakaliki
Levels of Cd, Ni, V and Pb in bonny light crude oil were investigated using atomic absorption spectrophotometer (model-Buck Scientific 210 VGP). The result revealed mean concentration of Cd (0.0485 ± 0.01 ppm), Ni (0.875...
Controlled Release Tablets of Zileuton by Using Gum Based and Hpmc Polymers
The aim of the present study was to develop Controlled release formulation of Zileuton to maintain constant therapeutic levels of the drug for over 12 hrs. Sodium alginate, Guar gum and HPMC K15M were employed as polymer...
Biochemical changes of Culex pipiens females infected with Plasmodium cathemerium
The present work aims to study the biochemical changes of Culex pipiens females infected with Plasmodium cathemerium. For achievement this research, females of Culex pipiens were infected with Plasmodium cathemerium to s...