Neuroprotective effect of ethanolic extract of Heliotropium indicum against transient global ischemia induced brain damage in rats
Journal Title: IOSR Journal of Pharmacy and Biological Sciences (IOSR-JPBS) - Year 2016, Vol 11, Issue 5
Abstract
Heliotropium indicum is a whole herb used as traditional medicine mainly in India for the treatment of mental disorders and as brain tonic since many years. The present study is to investigate the protective effects of ethanolic extract of whole herb of Heliotropium indicum on cerebral ischemia/reperfusion induced brain damage in rats. Cerebral ischemia was induced by occluding bilateral common carotid arteries for 60 min followed by 3h of reperfusion. Ischemia/reperfusion-induced neuronal injury was assessed by measurement of brain infarct area, biochemical estimations and histopathological studies. Pretreatment of Heliotropium indicum extract (200, 280 and 400 mg/kg, p.o.) significantly reduced the lipid peroxidation, increased the total thiol content, Catalase and glutathione-S-transferase activity in brain homogenates. The decreased cerebral infarction area in Extract-treated groups and histopathological sections confirmed the above findings. These observations reveal that Heliotropium indicum is a neuroprotective agent and may prove to be useful adjunct in the treatment of stroke and neurological disorders.
Authors and Affiliations
Dasarapu Santhosha*, Alluri Ramesh, Emandi Hemalatha2, Malothu Nagulu3
Keywords
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- EP ID EP386358
- DOI 10.9790/3008-1105030611
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