COLD PRESSOR TEST IN NORMOTENSIVE AND GRADE – I ESSENTIAL HYPERTENSIVE PATIENTS
Journal Title: Indian journal of applied basic medical sciences - Year 2018, Vol 20, Issue 30
Abstract
Background: Hypertension is creating not only health problems but also economical burden on working population in India. Autonomic nervous system (ANS) via its sympathetic and parasympathetic limbs plays a crucial role in maintaining the blood pressure (BP). Generally hypertensive population reacts differently as compared to normotensive to various forms of the stress.Aims and Objective: Present study was carried out to assess the role of ANS, specifically sympathetic nervous system in cardiovascular hemodynamics in Grade-I essential hypertensive subjects compared to normotensive along with the gender variation.Materials and Methods: Study included 80 volunteers of age 35 to 50 years, 40 normotensive subjects (20 Male and 20 Female) forms control group and 40 diagnosed Grade–I essential hypertensive (20 Male and 20 Female) forms study group. Systolic and diastolic BP of participants was measured at rest, at 30 and 60 seconds intervals during cold pressor test and at 1 minute interval till BP returns to resting value or at least 5 mm of Hg less than resting systolic BP after the cold pressor test. Then difference between rise in systolic and diastolic BP and resting BP was calculated and compared between control and study group’s males and females.Statistical analysis:Student‘s unpaired ‘t’ test was appliedand outcomes were presented as mean (SD).The ‘p’ value < 0.05 was considered as significant and < 0.001 as highly significant.Results:Study found highly significant rise in systolic and significant rise in diastolic BP of hypertensive male where as only significant rise in systolic BP of hypertensive females compared to normotensive group. In females, the rise of diastolic BP was more but it was not statistically significant. Recovery towards basal level was also slow in hypertensive male and female subjects. Conclusion: There is definite cardiovascular ANS dysfunction, specificallysympathetic in Grade–I essential hypertensive patients. More research work is needed to obtain precise relationship between ANS and hyper responsive response to stress in hypertensive patientsas regulation of BP has multiple components.
Authors and Affiliations
Lalita M, Gulhane Sonali
Keywords
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