Collapsing glomerulopathy in renal allograft biopsies: A study of five cases
Journal Title: Medpulse International Journal of Medicine - Year 2019, Vol 10, Issue 3
Abstract
Collapsing glomerulopathy (CG) is considered to be a distinct clinic pathologic pattern of proliferative podocyte injury. The clinical significance of CG in renal allograft biopsies is not yet clear due to the scant data on the occurrence of CG in renal transplant recipients. We identified nine cases of CG in allograft biopsies over a period of 1 year. Detailed clinical information, including follow-up data, was collected and histopathological analysis performed. All the five patients were males with a mean age at diagnosis of 37.8 years. The median posttransplantation duration at diagnosis was 36 (range 12–84) months. All the patients presented with severe proteinuria and graft dysfunction. Histological analysis showed a median number of 7 glomeruli. The collapse of the glomerular tuft with visceral epithelial cell hyperplasia involved median of 2 glomeruli (range 1–4).At the last follow-up (mean duration 6 months), two patients had graft failure (return to dialysis) while three had functioning grafts. This series emphasizes the importance of this rare glomerular pathology as an important cause of graft dysfunction that may lead to allograft failure.
Authors and Affiliations
RPSenthil Kumar, KSenthil Kumar, VBalaraman . , STirumalvalavan . , Murugesan .
A clinical profile and factors associated with carpel tunnel syndrome: Experience from tertiary centre
Background: Carpal tunnel syndrome (CTS) is the most commonly-encountered entrapment neuropathy and routinely seen mononeuropathy in busy neurology out patients departments. There is a need to study the clinical features...
Study of Hepatitis E infection in a tertiary care hospital in Western Maharashtra
Background: Hepatitis E is the most common cause of acute viral hepatitis in the adult population in India. Acute viral hepatitis E (HEV) is generally mild and self-limiting and resolves within six weeks, with no chronic...
A study of various factors associated with outcomes in the swine flu patients at tertiary health care centre
Background: Pandemic influenza A (H1N1) 2009 is a novel strain of influenza A virus evolved by genetic reassortment. The Influenza A H1N1 in humans can be a mild illness or in some people it may result in serious, even l...
A study of clinico- laboratory profile of the patients with type II diabetes at rural tertiary health care center
Background: The relationship between alteration of serum lipids and vascular complications is more significant in diabetics than in non diabetics amongst the general population. Lipid abnormalities will lead to microvasc...
Clinical and etiological profile of nephrotic syndrome in adults with assessment of response to treatment
Background: Nephrotic syndrome is defined as proteinuria 3 gms/24 hrs or more associated with spot urine albumin creatinine ratio of more than 300-350mg/mmol, sr.albumin <25g/l with evidence of peripheral edema with hype...