COLON ULCER INDUCED BY ALENDRONATE AND CURE IT WITH METHYL SULFONYL METHANE
Journal Title: World Journal of Pharmaceutical Research - Year 2019, Vol 8, Issue 3
Abstract
Background: Bisphosphonates define a class of drugs which are widely indicated to treat osteoporosis both in men and women. Side effects of the oral tablets may include nausea, difficulty swallowing, heartburn, irritation of the esophagus and gastric ulcer. Methylsulfonylmethane (MSM), which has become a popular dietary supplement, was used to treat Bisphosphonates ulceration. Our objective was studying the effect of MSM on treat colon ulcer induced by Alendronate (ALN) in rats using different doses of MSM. The experiments had been done on 8 white wistar rats for each group. The colon ulcer had been induced by administration of Alendronate (20mg/kg/day) by gavage for 4 days. MSM (400mg/kg/day) has been given, for the first therapeutic group, for 4 days after administration of Alendronate, while the other therapeutic group has been given MSM (800 mg/kg/day). The ulcers in rats' colon were examined histologically and microscopically. Results indicated the inability of MSM to treat the colonic ulceration induced by Alendronate in both doses 400 and 800 mg/kg/day for four days. Conclusion: MSM both doses (400 mg/kg/day) and (800 mg/kg/day) have no therapeutic effect of colon ulcer induced by alendronate.
Authors and Affiliations
Dr. Shaza Anwar Al Laham
Keywords
Related Articles
- EP ID EP671929
- DOI -
- Views 136
- Downloads 0
A REVIEW ON MANGROVE VEGETATION IN DIVISEEMA & MACHILIPATNAM REGIONS AND POTENTIAL APPLICATIONS OF THESE PLANTS IN NANOPARTICLE SYNTHESIS
Nanoscience is a field that is making a score in research day by day and making an impact in all spheres of human life. Biosynthesis of nanoparticles by means of physical and chemical processes is highly expensive. In or...
AYURVEDIC VEIWS ABOUT SPASTICITY AND FLACCIDITY
Muscle weakness is either spastic or flaccid type. Spasticity is due to increased tone of muscle and flaccidity is due to decreased tone of muscles. In both spasticity and flaccidity, there is majja dhatu dushti. But in...
COMPARATIVE STUDY OF VERTICAL MARGINAL FIT ON IMPLANT ABUTMENT USING METAL CERAMIC CROWNS, FULL CONTOUR ZIRCONIA CROWNS (CAD/CAM) AND VENEERED ZIRCONIA CROWNS (CAD/CAM) (AN IN VITRO STUDY)
Background: Marginal fitness is an important factor in success and longevity of implant – retained restoration. Poor fitness and too large discrepancy lead to seepage of debris, cement dissolution and microbial colonizat...
ETHNOBOTANY OF THE ACONITUM FEROX
Traditional medicines comprises of the utilization of the folk plants knowledge for the treatment of the many kinds of the disorders, as well as the folk knowledge which has assimilated over generations by the different...
ASCITES AND ELEVATED VALUES OF TUMOR MARKER CA 125 IN DISSEMINATED ENDOSALPINGIOSIS
Endosalpingoidosis, like endometriosis and endocervicosis, is a benign disease of the Müller system. There are several theories about the development and origin of endosalpingoidosis. Patients are most often asymptomatic...