Combination of omeprazole with GLP-1 agonist therapy improves insulin sensitivity and antioxidant activity in liver in type 1 diabetic mice.
Journal Title: Pharmacological Reports - Year 2013, Vol 65, Issue 4
Abstract
Combination with suitable pharmacological agents can improve the antiobesity and antidiabetic actions of glucagon like peptide-1 (GLP-1) based therapies. GLP-1 agonist exendin-4 may have insulin-independent effects on amelioration of insulin resistance and hepatic steatosis by virtue of its action on hepatic GLP-1 receptors, and these effects can be improved by combination with proton pump inhibitors. However, it was not assessed whether omeprazole can improve the peripheral actions of exendin-4 in the state of insulin deficiency.
Authors and Affiliations
Vishal Patel, Amit Joharapurkar, Nirav Dhanesha, Samadhan Kshirsagar, Jaysukh Detroja, Kartikkumar Patel, Tejal Gandhi, Kirti Patel, Rajesh Bahekar, Mukul Jain
Keywords
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