Lack of effect of some dopamine and non-dopamine receptor ligands on amphetamine-induced changes in the rat brain neuropeptide Y system.
Journal Title: Pharmacological Reports - Year 2005, Vol 57, Issue 6
Abstract
None of the receptor ligands studied: the dopamine D(2) antagonist eticlopride, D(2)/D(3) antagonist haloperidol, alpha(1)-adrenergic antagonist prazosin, N-methyl-D-aspartate antagonist MK-801, 5-HT(2)/D(2) antagonist mianserin, D(2)/D(3) agonist quinpirole and alpha(2)-adrenergic agonist clonidine co-administrated with repeated amphetamine (AMPH) injections blocked the AMPH-induced decrease in the striatal and nucleus accumbens neuropeptide Y (NPY) levels. Only the D(1)/D(5) receptor antagonist SCH 23390 insignificantly attenuated this effect what suggests that these dopamine receptor subtypes may partially mediate AMPH effect on NPY. Moreover, the results of multiple administrations of the receptor ligands to control rats indicate that the NPY systems in both structures under study are modulated in the same manner by dopaminergic activity and differentially by adrenergic, N-methyl-D-aspartate and serotonergic activity.
Authors and Affiliations
Ewa Obuchowicz, Zbigniew Herman
Keywords
Related Articles
- EP ID EP154552
- DOI -
- Views 115
- Downloads 0
Mydriasis model in rats as a simple system to evaluate α2-adrenergic activity of the imidazol(in)e compounds.
Imidazol(in)e compounds show the diversity of pharmacological effects including mydriasis, hypotension, sedation, bradycardia and hypothermia. At first it was postulated that these effects are mediated via α2-adrenocepto...
Gastric anti-ulcerative and anti-inflammatory activity of metyrosine in rats.
In this study, the anti-inflammatory and anti-ulcerative effects of metyrosine, a selective tyrosine hydroxylase enzyme inhibitor, were investigated in rats. For ulcer experiments, indomethacin-induced gastric ulcer test...
Vane's discovery of the mechanism of action of aspirin changed our understanding of its clinical pharmacology.
Aspirin exerts its analgesic, antipyretic and anti-inflammatory actions by inhibiting the enzyme cyclooxygenase and thus preventing the formation and release of prostaglandins. The elucidation by John Vane of the mechani...
Kynurenic acid and kynurenine aminotransferases in retinal aging and neurodegeneration.
The kynurenine aminotransferases (KATs) KAT I and KAT II are pivotal to the synthesis of kynurenic acid (KYNA), the only known endogenous glutamate receptor antagonist and neuroprotectant. KAT I and II have been found in...
Involvement of adenosine receptors in dizocilpine-induced motor activity in mice.
The effect of adenosine receptor ligands on dizocilpine-induced locomotion was studied in mice. Dizocilpine-induced hyperactivity (0.1 mg/kg ip) in mice was antagonized by all adenosine receptor agonists: CPA - A(1) rece...