Combination therapy in the treatment of pulmonary arterial hypertension - 2015 update.
Journal Title: Journal of Rare Cardiovascular Diseases - Year 2015, Vol 2, Issue 4
Abstract
Pulmonary arterial hypertension (PAH) is a disease with a poor prognosis and high mortality rates therefore in the era of advanced therapies targeting different patophysiological pathways attractive seems the idea of combining drugs from two or more classes. They can be applied sequentially or initially (upfront). Data from randomized clinical placebo controlled trials and observational studies show that both strategies can be successful in terms of improvement of functional capacity or delaying time to clinical worsening. The European Society of Cardiology guidelines on pulmonary hypertension issued in 2015 present in detail the role of combination therapy in the management of PAH.
Authors and Affiliations
Grzegorz Kopec, Piotr Podolec
Keywords
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- EP ID EP242018
- DOI 10.20418/jrcd.vol2no4.204
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