Combination therapy of tadalafil and pentoxifylline in severe erectile dysfunction; a prospective randomized trial
Journal Title: Polish Journal of Surgery - Year 2015, Vol 87, Issue 8
Abstract
The aim of the study was to assess efficacy of Tadalafil alone versus Tadalafil plus Pentoxifylline in the treatment of erectile dysfunction by using self administered IIEF-5 questionnaire. Material and methods. Two hundred and thirty seven patients presenting with ED at andrology OPD were evaluated for ED by a self administered IIEF (International Index of Erectile Function) questionnaire. Patients were systematically randomized by computer generated random table into two groups groups namely, group A: Tadalafil only group, group B: combination of Tadalafil + Pentoxifylline. All the patients were re-assessed by IIEF-5 questionnaire after 8 weeks of medical therapy. Statistical analysis was performed using student’s unpaired t-test, paired t-test, chi square test. pvalue < 0.05 was considered statistically significant. Results. Two hundred and thirty seven patients were included in the present study, in group A: 92 patients (78.6%) showed improvement in their IIEF score after 8 weeks of tadalafil treatment. While in group B, overall 104 patients(86.6%) showed improvement after combination of Tadalafil and Pentoxifylline. There was a statistically significant difference of percentage change in IIEF score was seen in group B (group A 90.7±15.2%, group B 95.6±13.4%; p value – 0.014). We found this difference even more statistically significant in patients with severe ED (group A 72.7±47.2%, group B 132.3±54.3%; p value – 0.000). There was no significant difference in between the two groups with regards to occurrence of side effects. Conclusions. Both tadalafil and combination of Tadalafil + Pentoxifylline improve erectile function in patients of ED. Patients with severe ED showed much significant improvement in erectile function with combination therapy.
Authors and Affiliations
Santosh Kumar, Rajesh Roat, Swat Agrawal, Kumar Jayant, Ravimohan Mavuduru, Shrawan Kumar
Keywords
Related Articles
- EP ID EP76964
- DOI -
- Views 130
- Downloads 0
Przeszczepienie trzustki u pacjenta po całkowitej pankreatektomii z powodu przewlekłego zapalenia trzustki – pierwszy przypadek w Pols
Przewlekłe zapalenie trzustki jest chorobą, która może wymagać interwencji chirurgicznej, w tym również niekiedy konieczności wykonania całkowitej pankreatektomii. Pacjenci po takim zabiegu muszą mieć wdrożoną insulinote...
The relative frequency of the Helicobacter pylori Infection in Proximal Gastric Cancers
Gastric cancer with the annual mortality of 700 000 is the second cause of death in the world. Iran with the annual incidence of 37 in 100 000 is among areas with high risk of gastric cancer. In Iran, Khuzestan Province...
Cysta pilonidalna – poszukiwanie optymalnej metody leczenia
Cysta pilonidalna to uciążliwe schorzenie dotykające zwykle ludzi młodych. Istotnie wpływa na jakość życia i powoduje obniżenie samooceny chorych. Mimo znanej patofizjologii i istnienia licznych metod leczniczych, cysta...
Richter Type of Incarcerated Obturator Hernia; Misery Still Continues
Obturator hernia is a rare type of hernia which accounts for only 0.07–1.4% of all intra-abdominal hernias and 0.2–5.8% of small-intestinal obstructions. It develops predominantly in elderly underweight women. It has non...
The Potential of Bacteriophages in the Treatment of Burn Wounds