Combined Analysis of Safety and Optimal Efficacy in UV-light-activated Corneal Collagen Crosslinking
Journal Title: Ophthalmology Research: An International Journal - Year 2016, Vol 6, Issue 2
Abstract
Aims: To analyze the combined factors for safety and optimal efficacy for UV-light-initiated corneal collagen cross-linking (CXL). Study Design: Modeling and analysis of CXL. Place and Duration of Study: New Vision Inc, Taipei, between Oct. 2015 and July 2016. Methodology: Analytic formulas were derived based on the coupled dynamic equations for the safety dose (E*), minimum corneal thickness and concentration of the riboflavin, and the cornea stiffness increase after the CXL. The critical parameters influencing the efficacy of CXL include: various absorption coefficients, initial concentration (C0) and diffusion depth (D) of the riboflavin solution, the quantum yield, the UV light intensity (I0) and dose (E), irradiation duration (t), the cytotoxic threshold dose of endothelial cells(E’) and the corneal thickness (z). Conclusion: The safety dose (E*) is an increasing function of the parameter set (D, z, C0) and has a range of 5.3 to 10.1 J/cm2 for cytotoxicity threshold 0.63 to 1.26 J/cm2. Minimum corneal thickness z* =(300, 400) um for dose of E*=(5.0, 10.1) J/cm2 which has a much wider range than the conventional safety dose 5.4 J/cm2 (with z*=400 um). For maximum efficacy, the optimal dose is 0.7 to 1.55 J/cm2. However, to achieve crosslink depth of 230 to 300 um, higher dose of 2.0 to 3.0 J/cm2 is recommended.
Authors and Affiliations
Jui-Teng Lin
Keywords
Related Articles
- EP ID EP327495
- DOI 10.9734/OR/2016/28712
- Views 149
- Downloads 0
Vitamin D Deficiency may be a Risk Factor for Ophthalmopathy in Patients with Graves’ Hyperthyroidism But Not Hashimoto's Thyroiditis
Aims: Apart from its key role in bone metabolism vitamin D plays a role in immune function, cancer prevention and autoimmunity induction. Vitamin D insufficiency (25-50 nmol/L) and deficiency (serum level < 25 nmol/L) ar...
Recurrent Radiation Retinopathy and Optic Neuropathy after Cranial Irradiation Therapy Treated by Intravitreal Bevacizumab
Purpose: To report a case of radiation retinopathy and optic neuropathy after head irradiation therapy treated by intravitreal triamcinolone and bevacizumab Methods: Case report. Case: A 38 year old woman presented with...
Prospective Pilot Study Looking at the Size and Variation of the Blind Spot Scotoma in Adults Measured on the Octopus 900 Field Analyser
Aims: Literature regarding the size of the blind spot is old and recorded on instruments no longer in production. This pilot study looks to provide normative data for the size of the visual blind spot scotoma in adults m...
Fast Eye Movements and Slow Eye Movements in Congenital Neurosensorial Deaf Subjects as Assessed by 2D video-Oculography™
Aims: There is evidence that the deprivation of a sensory system at early developmental stage may lead to a functional change of the remaining one(s). Even if this process has been widely studied, results are still cont...
Aldose Reductase Inhibitors for Diabetic Cataract: A Study of Disclosure Patterns in Patents and Peer Review Papers
Aims: To investigate, for 13 aldose reductase inhibitors that had been in development for diabetic cataract, whether patent documents could provide earlier dissemination of knowledge to the ophthalmology community than p...