Commentary: Stochastic phenomena in pharmacokinetic, pharmacodynamic, and pharmacogenomic models
Journal Title: The AAPS Journal - Year 2005, Vol 7, Issue 1
Abstract
Authors and Affiliations
Ronald A. Siegel, Murali Ramanathan
Ronald A. Siegel, Murali Ramanathan
A Mass Balance-Based Semiparametric Approach to Evaluate Neonatal Erythropoiesis
Postnatal hemoglobin (Hb) production in anemic preterm infants is determined by several factors including the endogenous erythropoietin levels, allogeneic RBC transfusions administered to treat anemia, and developmental...
Toward the Establishment of Standardized In Vitro Tests for Lipid-Based Formulations, Part 6: Effects of Varying Pancreatin and Calcium Levels
The online version of this article (doi:10.1208/s12248-014-9672-x) contains supplementary material, which is available to authorized users.
Inhalation Devices and Patient Interface: Human Factors
The development of any inhalation product that does not consider the patient needs will fail. The needs of the patients must be identified and aligned with engineering options and physical laws to achieve a robust and in...
Development of a multidose formulation for a humanized monoclonal antibody using experimental design techniques
The purpose of this study was to identify optimal preservatives for a multidose formulation of a humanized monoclonal antibody using experimental design techniques. The effect of antimicrobial parenteral preservatives (b...
L-methionine reduces oxidant stress in endothelial cells: Role of heme oxygenase-1, ferritin, and nitric oxide
The amino acid L-methionine is known to exert antioxidant effects by as yet unidentified mechanisms. In the present study, L-methionine led to a concentration-dependent induction of the antioxidant protein heme oxygenase...