Commentary: Stochastic phenomena in pharmacokinetic, pharmacodynamic, and pharmacogenomic models
Journal Title: The AAPS Journal - Year 2005, Vol 7, Issue 1
Abstract
Authors and Affiliations
Ronald A. Siegel, Murali Ramanathan
Ronald A. Siegel, Murali Ramanathan
Haste Makes Waste: The Interplay Between Dissolution and Precipitation of Supersaturating Formulations
Contrary to the early philosophy of supersaturating formulation design for oral solid dosage forms, current evidence shows that an exceedingly high rate of supersaturation generation could result in a suboptimal in vitro...
A Kinetic Degradation Study of Curcumin in Its Free Form and Loaded in Polymeric Micelles
The online version of this article (doi:10.1208/s12248-015-9863-0) contains supplementary material, which is available to authorized users.
Relationships between Liposome Properties, Cell Membrane Binding, Intracellular Processing, and Intracellular Bioavailability
Positive surface charge enhances liposome uptake into cells. Pegylation, used to confer stealth properties to enable in vivo applications of cationic liposomes, compromises internalization. The goal of this study was to...
Biomarker qualification pilot process at the US Food and Drug Administration
New biomarkers of safety and efficacy are becoming powerful tools in drug development. Their application can be accelerated if a consensus can be reached about their qualification for regulatory applications. This consen...
Modification of Disodium Cromoglycate Passage Across Lung Epithelium In Vitro Via Incorporation into Polymeric Microparticles
Two microparticle systems containing disodium cromoglycate (DSCG) alone or with polyvinyl alcohol (DSCG/PVA) were produced via spray drying and compared in terms of their physicochemical characteristics, aerosol performa...