Comparative 2D QSAR Studies of 1,8-Naphthyridine against Tumor Cell Lines
Journal Title: Journal of Pharmacology and Biomedicine - Year 2017, Vol 1, Issue 5
Abstract
In a persevering effort to develop better anticancer drugs, a quantitative structure activity relationship analysis using a set of 2-D descriptors was performed on a series of 1,8- naphthyridine derivatives acting by the inhibition of tubulin polymerization. QSAR models that were derived from the study were found to be statistically significant with a good predicting ability. The results obtained from the study justify the use of 2-D descriptors for exploring the requirements of binding of 1,8-naphthyridines to the heterodimer, tubulin. Attempt has been made to explore the structural and/or physicochemical requirements of the compounds, responsible for the action against tumor cells. The physicochemical descriptors and indicator variables were correlated with the biological activity
Authors and Affiliations
Brijeshkunvar Mishra, Richa Mishra
Keywords
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