Comparative Acute Toxicity Studies of Selected Indigenous Herbal Plants in Swiss Albino Mice
Journal Title: IOSR Journal of Pharmacy and Biological Sciences (IOSR-JPBS) - Year 2016, Vol 11, Issue 3
Abstract
Objective: Toxicology may be defined as the study of harmful / poisonous effects of drugs and other chemicals with emphasis on detection, prevention and treatment of poisonings. The present study was aimed to determine LD50 and to establish the safety margin ofdifferent solvent extracts of selected herbal plants sources namelySaussurea lappa (Root), Ficus bengallensis (Root ), Flacourtria romantchi (stem bark and Root), andOroxyllum indicum (Root ) by acute toxicity study in Swiss albino mice as per OECD guideline 425. Methods: Swiss albino mice were sequentially administered all the extracts in single dosages of 250, 500, 750, 1000, 1500, 2000 mg/kg of body weight. All the animals were individually studied for mortality, wellness parameters and body weight for 24 hours. Results: No mortality and no significant changes were observed in body weight and wellness parameters at 250, 500 and 750 mg/kg body wt. doses, which reveal the safety of these extracts in the doses up to 1000 mg/kg body weight. Conclusion: Conclusively, LD50 value of all extracts of Saussurea lappa (Root), Ficus bengallensis (Root ), Flacourtria romantchi (stem bark and Root), and Oroxyllum indicum was found to be more than 1000 mg/kg body weight.
Authors and Affiliations
Ram Garg1 ,, Rahul Kumar, Deepak Nathiya1, Omprakash Goshain2, Vinita Trivedi3 ,, Ashish Kumar Sharma, ,Krishna Murti4
Keywords
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