Comparative analysis of choice reaction times with randomly variable foreperiods in normal individuals and schizophrenic patients
Journal Title: National Journal of Physiology, Pharmacy and Pharmacology - Year 2017, Vol 7, Issue 10
Abstract
Background: Reaction time (RT) is an index of brain’s biological efficiency. RT can indicate sensorimotor variability with varying foreperiods (FPs) and can indicate mental dysfunction like schizophrenia. Aims and Objective: Objective was to analyze the effect variable FPs on RTs in controls and schizophrenic patients. Materials and Methods: The study was conducted at Topiwala National Medical College, Mumbai, on 80 normal controls and 80 schizophrenic patients in the age group of 20-50 years. Digital RT apparatus (RTM-608) manufactured by Bio-Tech., with a maximum resolution time of 0.0001 s was used. Auditory RT (ART) and visual RT (VRT) with randomly variable FPs (2, 4, and 6 s) were recorded in controls and schizophrenic patients. Results: Two-way ANOVA with replication in MS Office Excel was used to analyze results. ARTs and VRTs in schizophrenic patients were significantly slower than that in controls with P = 1.4336E-215 with F = 6779.53969 and P = 2.5966E-209 with F = 6161.152654, respectively. The condition effect was also significant with ARTs and VRTs, increasing in patients with increase in the FPs with P = 4.84285E-16 with F = 73.35131426 (ART) and P = 2.72532E-14 with F = 63.68037666 (VRT), respectively. The Group X condition interaction also was significant with P = 8.80207E-12 with F = 50.27084108 in case of ARTs and P = 1.21054E-10 with F = 44.36301991 in case of VRTs. Conclusion: This shows that variation in FPs results in slower RTs in schizophrenic patients than in controls.
Authors and Affiliations
Gaurang G Bhandarkar, Surendra S Wadikar
Keywords
Related Articles
- EP ID EP291976
- DOI 10.5455/njppp.2017.7.0516716052017
- Views 40
- Downloads 0
Knowledge, attitude, and practice of adverse drug reaction reporting among nurses in a South Indian tertiary health-care center
Background: Nurses who are bedside caregivers have a unique position monitoring patient’s drug therapy, and they are the ones who observe adverse drug reactions (ADRs) first hand. Knowledge of ADRs and practice of pharma...
Beneficial effects of yogasanas and pranayama in limiting the cognitive decline in Type 2 diabetes
Background: Out of many complications that were observed in Type 2 diabetes, cognitive impairment is the most neglected. Aim and Objectives: The aim of the present study is to assess the cognitive decline in Type 2 diabe...
Anemia as a comorbidity in chronic obstructive pulmonary disease - A hospital-based study in East Sikkim
Background: Chronic obstructive pulmonary disease (COPD) is a chronic airway obstruction due to chronic inflammation. This entity is one of the major causes of premature mortality and morbidity in adults. Anemia is known...
Waist-related anthropometric measures: Simple and useful predictors of coronary heart disease in women
Background: Waist circumference (WC) (abdominal girth), a measure of both subcutaneous and visceral fats, is easily measured and also correlated with body frame size. Waist circumference (WC) a...
Perception of stress in first-year MBBS, BDS, and BPTh students
Background: Stress is a complex dynamic process of interaction between a person and his or her own life. Medical education is perceived as being stressful and characterized by many psychological changes in students. Aims...