Comparative analysis of choice reaction times with randomly variable foreperiods in normal individuals and schizophrenic patients
Journal Title: National Journal of Physiology, Pharmacy and Pharmacology - Year 2017, Vol 7, Issue 10
Abstract
Background: Reaction time (RT) is an index of brain’s biological efficiency. RT can indicate sensorimotor variability with varying foreperiods (FPs) and can indicate mental dysfunction like schizophrenia. Aims and Objective: Objective was to analyze the effect variable FPs on RTs in controls and schizophrenic patients. Materials and Methods: The study was conducted at Topiwala National Medical College, Mumbai, on 80 normal controls and 80 schizophrenic patients in the age group of 20-50 years. Digital RT apparatus (RTM-608) manufactured by Bio-Tech., with a maximum resolution time of 0.0001 s was used. Auditory RT (ART) and visual RT (VRT) with randomly variable FPs (2, 4, and 6 s) were recorded in controls and schizophrenic patients. Results: Two-way ANOVA with replication in MS Office Excel was used to analyze results. ARTs and VRTs in schizophrenic patients were significantly slower than that in controls with P = 1.4336E-215 with F = 6779.53969 and P = 2.5966E-209 with F = 6161.152654, respectively. The condition effect was also significant with ARTs and VRTs, increasing in patients with increase in the FPs with P = 4.84285E-16 with F = 73.35131426 (ART) and P = 2.72532E-14 with F = 63.68037666 (VRT), respectively. The Group X condition interaction also was significant with P = 8.80207E-12 with F = 50.27084108 in case of ARTs and P = 1.21054E-10 with F = 44.36301991 in case of VRTs. Conclusion: This shows that variation in FPs results in slower RTs in schizophrenic patients than in controls.
Authors and Affiliations
Gaurang G Bhandarkar, Surendra S Wadikar
Keywords
Related Articles
- EP ID EP291976
- DOI 10.5455/njppp.2017.7.0516716052017
- Views 80
- Downloads 0
Does visceral fat affect aerobic fitness in Indian adolescents of 18-19 years’ age group?
Background: Cardiovascular endurance tests are considered as one of the best methods for assessment of the individual’s health. Reduced aerobic fitness is seen in overweight and obese. Aerobic fitness is also reduced in...
Early detection of auditory dysfunctions in patients with overt hypothyroidism
Background: Widespread metabolic derangements in overt hypothyroidism have also been suggested to involve adult human brain with the involvement of cochlea and other inner ear structures. More interestingly, abnormal ele...
Evaluation of the impact of cigarette smoking on platelet parameters
Background: Smoking has been established as a chief causative factor for cardiovascular diseases, inflammatory disorders, and oxidative stress stimulation. It is known that the total peripheral blood leukocyte cou...
Short term memory in obese and non-obese female school children
Background: Obesity affects some vital parts of the brain such as pre-frontal cortex (responsible for short-term memory), hippocampus (responsible for long-term memory) frontal and temporal lobes (required for planning a...
Assessment of knowledge, attitude, and practices of pharmacovigilance and adverse drug reaction reporting among final year medical students - A questionnaire-based study in a tertiary care hospital in Goa
Background: Pharmacovigilance has a significant role in the rational use of medicines by providing information about adverse drug reactions (ADRs). ADRs can lead to significant mortality and morbidity in the health-care...