Evaluation of the impact of cigarette smoking on platelet parameters
Journal Title: National Journal of Physiology, Pharmacy and Pharmacology - Year 2015, Vol 5, Issue 5
Abstract
Background: Smoking has been established as a chief causative factor for cardiovascular diseases, inflammatory disorders, and oxidative stress stimulation. It is known that the total peripheral blood leukocyte count increases by cigarette smoking; however, its influence on platelet parameters is largely unknown. Early detection of thromboembolic diseases can be achieved by the potentially useful platelet indices. Enhanced activity is shown by platelets with increased volume when compared with platelets with smaller volume. Hence, mean platelet volume (MPV) can act as a indicator for platelet activity. Aims and Objective: To study the impact of cigarette smoking on platelet parameters. Materials and Methods: This crosssectional study included 50 healthy young male cigarette smokers and 50 healthy male nonsmokers in the age range of 18–50 years at SRM Medical College, Tamil Nadu, India, after approval by the institutional ethical committee. Subjects with acute illness and diabetes mellitus and those on antiplatelet drugs were excluded. History regarding current smoking status, number of cigarettes smoked per day, pack-years of smoking, and years since quitting was noted. Complete blood count including platelet indices such as platelet count, MPV, platelet distribution width (PDW), platelet large cell ratio (P-LCR), and plateletcrit (PCT) were determined. On the basis of their smoking characteristics, smokers were grouped as mild, moderate, and heavy. Result: Compared with nonsmokers, smokers showed significantly high values of MPV, and PDW (P o 0.05). MPV, PDW, and P-LCR were found to be positively associated with intensity of smoking, pack-year, and duration of smoking. Conclusion: The smokers showed higher MPV, PDW, and P-LCR, which might forecast possible high risk for developing thromboembolic disease in smokers.
Authors and Affiliations
Anandhalakshmi Swaminathan, Kalaivani Amitkumar, Shivasekar Ganapathy, Saravanan Ayyavoo
Keywords
Related Articles
- EP ID EP164636
- DOI 10.5455/njppp.2015.5.1009201570
- Views 71
- Downloads 0
Comparative study on the effect of yogic relaxing asanas and pranayamas on cardiovascular response in healthy young volunteers
Background: Cardiovascular morbidity is increasing recently in India. Stress and autonomic dysfunction are associated with cardiovascular morbidity. Yoga is the best lifestyle ever designed. Based on limited scientific r...
Assignment-based learning of essential medicine list concepts among undergraduate medical students
Background: The concepts of essential medicines and rational drug therapy are necessary to be understood undergraduate students. Aims and Objectives: (i) To make the second MBBS students aware regarding essential medicin...
Brainstem auditory evoked potentials in the older population
Background: The central nervous system is no exception to the effects of aging. Physiologic changes due to aging have been suggested to impair the neurotransmission in the auditory pathways. Brainstem auditory evoked pot...
H-reflex conduction velocity in babies from birth to 6 month of age
Background: The neurological assessment of newborn babies is clinically difficult due to its subjectivity. H-reflex and H-reflex conduction velocity (HRCV) are especially useful in pediatric nerve conduction studies. It...
Association of ABO and Rh blood groups with type 2 diabetes mellitus in Muzaffarnagar city
Background: The “ABO” blood group system is associated with some diseases including gastric and duodenal ulcer, hepatitis B1, vascular diseases, abdominal aortic aneurism, and cancers. Some epidemiological studies demons...