Comparative Analysis of Espa-Carb Efficacy in Patients with Hyperthyroidism
Journal Title: Міжнародний ендокринологічний журнал - Year 2014, Vol 4, Issue 60
Abstract
The article discusses approaches to conservative treatment in patients with diffuse toxic goiter (DTG). The purpose of research — evaluation of coverage, therapeutic efficacy and tolerability of carbimazole (Espa-Carb) compared with thiamazolum (Mercazolil-Zdorovye) in patients with hyperthyroidism. Materials and Methods. We observed 55 patients with DTG, divided into two groups. The first group (n = 30) received carbimazole (Espa-Carb), the second group (n = 25) — thiamazolum (Mercazolil-Zdorovye). The patient groups did not differ in age, sex, size of thyroid gland and duration of thyrotoxicosis. Results. Analysis of the findings shows that the first group of patients has a more significant effect of treatment compared with patients of the second group. Average thyroid volume was significantly reduced only in the first group. At average, thyroid volume decreased from 37.2 ± 3.1 cm3 to 29.3 ± 2.9 cm3 (p < 0.05). In the second group we observed a tendency to decrease, but without statistical significance (from 36.4 ± 3.9 cm3 to 32.4 ± 2.8 cm3 (p > 0.05). In patients from the first group with DTG, a significant increase in TSH (from 0.027 ± 0.009 mIU/l to 0.37 ± 0.16 mIU/L; p < 0.05) and a significant decrease in the levels fT4 (from 29.3 ± 2.3 nmol/l to 18.4 ± 1.8 nmol/l; p < 0.05) and fT3 (from 7.8 ± 1.6 nmol/l to 3.2 ± 1.1 nmol/l; p < 0.05) were detected. At this, TSH increase in patients of the second group did not reach a statistical significance (p > 0.05). At the same time, the second group of patients reported a significant decrease in the levels fT4 (from 31.4 ± 2.1 nmol/l to 21.7 ± 1.8 nmol/l; p < 0.05) and fT3 (from 8.2 ± 1.4 nmol/l to 3.7 ± 1.2 nmol/l, p < 0.05). Reduced autoimmune aggression manifested by a decrease in concentration of antibodies to rTSH which in patients of the first group became statistically significant. If the average daily dose of Espa-Carb and Mercazolil-Zdorovye at the baseline did not differ in the examined groups of patients, then after 6 months of treatment, the mean dose of carbimazole in the first group was 15.8 ± 1.7 mg, and the second group — 19.2 ± 2.1 mg (p > 0.05). Side effects weren’t observed for six months during the treatment of patients in both groups. Normalization of peripheral hormones (fT4 and fT3) in 90 days of observation has been achieved in 96.2 % of patients in the first group and 74.1 % — in the second group. The number of patients who achieved normal TSH levels was significantly higher in the first group (93.3 % vs. 76 %). Conclusions. We determined higher efficiency of carbimazole compared to thiamazolum that manifested by more rapid achievement of clinical effect and compensation thyrotoxicosis, significant decrease of thyroid volume, the level of antibodies to the TSH receptor. Using carbimazole reduces thyreostatics daily dose in patients with DTG, which reduces the risk of complications of therapy. When using carbimazole for six months in patients with DTG, cases of intolerance or other adverse effects weren’t reported.
Authors and Affiliations
V. I. Pankiv
Keywords
Related Articles
- EP ID EP226932
- DOI -
- Views 58
- Downloads 0
The Eye as an Antecedent Symptom for Cardiovascular Disease in Patients with Diabetes Mellitus (Pathogenetic Aspect and Clinical Implementation)
The authors carried out review of the literature concerning the increased occurence of cardiovascular disease and mortality in patients with diabetes under conditions of inadequate glycemic control. There has been proved...
Development Сoncept of Medical Science and Guidelines of Researches in Scientific Institutions of National Academy of Medical Sciences for 2013–2015 (Draft)
.
The Case of Combined Empty Sella Syndrome and Adrenal Tumor with Pseudo Precocious Puberty in 4 Years Old Boy
It is described a case of combined empty sella syndrome and adrenal tumor with pseudo precocious puberty in 4 years old boy. Before the operative treatment of adrenal tumor pseudo precocious puberty was determined, then...
Girls Precocious Sexual Development: Capability of Laboratory Diagnosis
The importance of timely detection of the causes of precocious sexual development is associated, firstly, with the possible existence of tumor, as well as with the states accompanied by the accelerated puberty. Key role...
Analysis of Indicators of Diabetes Care Quality in the World and Ways to Optimize the Evaluation and Monitoring of Diabetes Care Quality in Ukraine
Control and monitoring of diabetes care quality — a strategic goal of public health service in each country. The objective of the study — to analyze indicators of diabetes care quality around the world and their possible...