Comparative analysis of sympathetic nervous system activity in pre‑menopausal and post-menopausal women
Journal Title: National Journal of Physiology, Pharmacy and Pharmacology - Year 2017, Vol 7, Issue 9
Abstract
Background: Post-menopausal women suffer from various complications like autonomic dysfunction which predisposes them to cardiovascular morbidity. Decline in estrogen levels after menopause is associated with increased cardiovascular risks. Timely evaluation of such derangements and active intervention can play an important role in the prevention of cardiovascular morbidity. Aims and Objective: The aim is to compare the sympathetic autonomic nervous system activity in pre-menopausal and age-matched post-menopausal women. Materials and Methods: This study was conducted on two groups of 40 women each. Group I included pre-menopausal women and Group II included post-menopausal women. Sympathetic nervous system assessment was done using cold pressor test (CPT), handgrip test (HGT), and blood pressure (BP) response to standing. Statistical analysis was performed using Student’s t-test. Results: Evaluation of sympathetic functions between the two groups showed that the mean rise in systolic BP (SBP) in response to CPT was lower in Group I than in Group II (P < 0.01). Mean rise in the diastolic BP (DBP) in response to HGT was also lower in Group I as compared to Group II (P < 0.01). Fall in SBP on standing in Group I was more than in Group II (P < 0.01). Conclusion: Sympathetic nervous system evaluation showed sympathetic hyperactivity in the post-menopausal group as compared to the premenopausal group.
Authors and Affiliations
Sheveta Dureja Dureja, Vikram Bhandari, Kailash Chander Manchanda, Ram Sarup Sharma, Mridu Gupta, Rachna Bachhel
Keywords
Related Articles
- EP ID EP291947
- DOI 10.5455/njppp.2017.7.0514611052017
- Views 63
- Downloads 0
A cross-sectional study of association of body mass index and VO2 max by nonexercise test in medical students
Background: There is an increasing trend of obesity and it affects the physical fitness and person’s work output in medical students. VO2 max indicates person’s cardiovascular fitness. Aims and Objectives: (i) To evalua...
Effect of physical therapy on blood glycemic parameters in women with Type 2 diabetes mellitus
Background: Diabetes mellitus is a group of metabolic complications designated by chronic hyperglycemia due to insulin resistance. Regular exercises are playing a major role in the prevention and therapeutic treatment of...
Drug dispensing practices in private pharmacies in Goa
Background: In India, patients self-order both over-the-counter and prescription-only drugs in pharmacies, although the dispensing of the latter without a prescription is unlawful. Good pharmacy practice (GPP) guidelines...
Nootropic activity of ethanolic extract of Alangium salvifolium leaves on Scopolamine mouse model of Alzheimer’s disease
Background: Alangium salvifolium possesses completely different medicine activities such as antioxidant, anticancer, antiinflammatory, bactericide, antifungal, and antifertility. It is also employed in the treatment of a...
Cardiotoxicity associated with 5-flurouracil – A case series
5-flurouracil (5-FU) is a frequently administered chemotherapeutic drug in various malignant neoplasms. We report four cases of cancer patients who were exposed to 5-FU and which resulted in cardio toxicity. Patients dev...