Comparative assessment of effects of calcium channel antagonists, amlodipine, and cilnidipine, on QT interval in hypertensive patients - An observational study
Journal Title: National Journal of Physiology, Pharmacy and Pharmacology - Year 2018, Vol 8, Issue 4
Abstract
Background: The duration of the QT interval as measured by 12-lead electrocardiography is a measure of myocardial repolarization and is widely used to describe cardiac abnormalities, to determine the presence of cardiac toxicity and to evaluate drug safety. In hypertension, the QT interval is a predictor of the risk of both coronary events and cardiovascular death, after adjusting for the effects of additional risk factors. According to AHA and JNC VIII calcium channel blockers are first-line drug in the treatment of hypertension. The equipotent antihypertensive effect of cilnidipine and amlodipine in their equivalent dose has been demonstrated in number of studies. Aims and Objectives: To compare and evaluate the effects of calcium channel antagonists amlodipine and cilnidipine on QT interval among hypertensive patients. Materials and Methods: A total of 258 patients were screened, examined, and enrolled as study participants during that period. The enrolled patients were then divided as (1) hypertensive patient (n = 159) - selected patients received either amlodipine (2.5–10 mg) or cilnidipine (5–20 mg) with or without angiotensin receptor blocker (ARB) and (2) hypertensive with controlled diabetic patients (n = 99) - selected patients received either amlodipine (2.5–10 mg) or cilnidipine (5–20 mg) with or without ARB along with antidiabetic medication. Calculated by Bazett’s formula (most commonly used) = QT Interval/√ (relative risk [RR] interval) where RR interval = 60/heart rate, normal QTc ≤440 ms. The QT interval was measured at the baseline and after 12 months of treatment for hypertensive patients. Results: There was extremely significant QTc reduction was seen with cilnidipine therapy and significant elevation seen by amlodipine treatment but without any clinical relevance. While comparing the effect of amlodipine and cilnidipine, extremely significant as well as clinically relevant difference between the two treatments was noted. Conclusions: From this study, it can be concluded that cilnidipine reduces QTc interval, and hence is a better choice over amlodipine for patients suffering from long QT interval.
Authors and Affiliations
Sougata Sarkar, Vartika Srivastava, Manjushree Mohanty
Keywords
Related Articles
- EP ID EP487768
- DOI 10.5455/njppp.2017.7.0937418112017
- Views 51
- Downloads 0
Perceptions about normal physiological changes during adolescence and assessment of the impact made through an educational intervention program for adolescents in school children in a rural set up in Gujarat
Background: Adolescence is a period full of life marked by various changes such as biological, social, and psychological changes. Adolescence age group is particularly important seeing to the fact that this is a vibrant...
A comparative study of taste sensitivity to phenylthiocarbamide in pregnant and nonpregnant females
Background: Pregnancy is a condition where various neuroendocrinal changes occur. During pregnancy there are drastic changes especially in steroid hormone levels e.g. Estrogen and progesterone. Recent studies have shown...
Protective potential of ginseng and silymarin on the liver and kidney of ethanol-treated mice (Mus musculus)
Background: Alcohol use and abuse have been rampant worldwide, and therapeutic regimen has been sought for to ameliorate changes brought about by such. Herbal medicines have been mostly used due to their inherent propert...
Effects of chronic ingestion of Bisphenol A on gut contractility in rats
Background: Bisphenol A (BPA) is a plastic toxin widely used in manufacturing of plastic containers. It is known to produce a variety of toxic effects on body functions including reproduction, metabolism, and development...
Metaphors and symbols in drug promotional literature distributed by pharmaceutical companies
Pharmaceutical drug promotional literature is an important method of spreading the information regarding the drug to physicians. It is observed that physicians do get influenced by these drug promotional literature. Vari...