Comparative Assessment of Ginger and Cassava Starch as a Binder on Ibuprofen Tablet Formulation
Journal Title: SSR Institute of International Journal of Life Sciences (SSR-IIJLS) - Year 2018, Vol 4, Issue 3
Abstract
Using the wet granulation method of tablet formulation, ibuprofen tablets were formulated with binder concentration of 2%, 4% and 6% w/w respectively. The compressional, mechanical and dissolution properties were analyzed using density, crushing strength and dissolution methods. The result obtained shown that tablets made with ginger starch had acceptable crushing strength and dissolution rate. The disintegration time for 2%, 4% and 6% w/w ginger starch were 22.25, 17.07 and 33.17 minutes respectively and that for cassava starch 34.24, 29.16 and 33.35 minutes respectively. The 2% w/w of the ginger and cassava starches did not fall within the standard limit of the hardness test (4–8 kg) but rather values of 8.55 kg and 8.45 kg respectively was obtained and this may be linked to the thresh hold of the binders concentration not being attained. All the formulations passed the qualitative analysis but that consisting of 4% w/w ginger starch performed excellently in the entire tests hence ginger starch of such concentration could be a very suitable excipient for ibuprofen tablet formulation as compared to cassava starch of the same percentage composition.
Authors and Affiliations
Ordu JI, Onyemelukwe JI
Keywords
Related Articles
- EP ID EP670944
- DOI 10.21276/ijlssr.2018.4.3.15
- Views 114
- Downloads 0
Isolation and Characterization of Pigments from Marine Soil Microorganisms
Bacterial pigments have many applications in current day to day life. The pigments produced by chromobacteria can be used for various applications like dairy, pharmaceutical, and food etc. In this study, three types of p...
Mutilated Occlusion Fixed-Removable Approach- A Case Report
Partial or complete edentulism has multiple implications in relation to function, esthetics and future rehabilitative treatment. This case report illustrates the management of a patient with extreme consequences of parti...
Studies on Macroscopic, Microscopic, and TLC Based Phytochemical Analysis of Euphorbia thymifolia Linn.
Euphorbia thymifolia L. (Euphorbiaceae) is a small branched plant. The leaves, seeds and fresh juice of the whole plant are used in worm infections, as stimulant. Phenols are present in large amount in this plant which h...
Study the Effects of Vermicompost Prepared by Decoction Tea Powder on Abelmoschus esculentus
The present study was carried on Abelmoschus esculentus (A. esculentus) by using the vermicompost. The decoction tea powder is wasted wet garbage and discarded on the dumping ground. It generally creates environmental po...
Nipah Virus- Infectious Agent: An Overview
Nipah virus (NiV) is extremely pathogenic in nature, recently emerged paramyxovirus that has been dependable for scattered outbreaks of metastasis and encephalitic ill health in Southeast Asia. The multiplied urbanizatio...