Comparative Assessment of Ginger and Cassava Starch as a Binder on Ibuprofen Tablet Formulation
Journal Title: SSR Institute of International Journal of Life Sciences (SSR-IIJLS) - Year 2018, Vol 4, Issue 3
Abstract
Using the wet granulation method of tablet formulation, ibuprofen tablets were formulated with binder concentration of 2%, 4% and 6% w/w respectively. The compressional, mechanical and dissolution properties were analyzed using density, crushing strength and dissolution methods. The result obtained shown that tablets made with ginger starch had acceptable crushing strength and dissolution rate. The disintegration time for 2%, 4% and 6% w/w ginger starch were 22.25, 17.07 and 33.17 minutes respectively and that for cassava starch 34.24, 29.16 and 33.35 minutes respectively. The 2% w/w of the ginger and cassava starches did not fall within the standard limit of the hardness test (4–8 kg) but rather values of 8.55 kg and 8.45 kg respectively was obtained and this may be linked to the thresh hold of the binders concentration not being attained. All the formulations passed the qualitative analysis but that consisting of 4% w/w ginger starch performed excellently in the entire tests hence ginger starch of such concentration could be a very suitable excipient for ibuprofen tablet formulation as compared to cassava starch of the same percentage composition.
Authors and Affiliations
Ordu JI, Onyemelukwe JI
Keywords
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- EP ID EP670944
- DOI 10.21276/ijlssr.2018.4.3.15
- Views 98
- Downloads 0
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