Comparative assessment of oxidative stress and enzymatic antioxidants in primigravidae pregnant and non-pregnant women
Journal Title: Medpulse International Journal of Biochemistry - Year 2019, Vol 9, Issue 2
Abstract
Background: The generation of reactive oxygen species and the activation of antioxidant defence mechanisms are important components of female reproductive physiology. It's impairment alters cellular signalling and can damage cellular macromolecules. Consequently, oxidative stress has emerged as a likely promoter of several pregnancy-related disorders, such as spontaneous abortions, embryopathies, preeclampsia, foetal growth restriction, preterm labour and low birth weight. Aims: The present study aimed to investigate the status of malondialdehyde (MDA), superoxide dismutase (SOD), catalase and glutathione peroxidase (GSH-P) with age matched pregnant & nonpregnant women. Methods & Materials: Blood samples were collected during the ante partum period of primi gravidae pregnant women and in non - pregnant women. Study subjects were matched with respect to maternal and gestational age in all the three trimesters. Results: MDA levels were significantly increased whereas the levels of enzymatic antioxidant's i.e. SOD, CATALASE and glutathione peroxidase were significantly decreased in pregnant women as compared to non –pregnant women. Conclusion: These results suggest that an equilibrium maintained between the production of free radicals and antioxidant production during pregnancy ensures healthy maternal and foetal growth.
Authors and Affiliations
Juhi Aggarwal, Niharika Singh, Mayur Kumar
Keywords
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- EP ID EP521718
- DOI 10.26611/1002927
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