25(OH) vitamin D level and severity of chronic liver disease: A controlled study from Eastern India
Journal Title: Medpulse International Journal of Biochemistry - Year 2017, Vol 4, Issue 3
Abstract
Background: Chronic Liver Disease (CLD) is defined as long term process of progressive degeneration and regeneration of liver cells and with advancement, leads to hepatic fibrosis, scarring, and cirrhosis. 25(OH) Vitamin D undergoes post synthesis processing in liver and in CLD, Vitamin D homeostasis is impaired. Active metabolite of Vitamin D 1,25 (OH)D3 is involved in calcium and phosphate metabolism. CLD is associated with cholestatic liver disease like primary biliary cirrhosis and many patients develop osteoporosis due to altered calcium and Vitamin D metabolism. Aims and Objectives: The aim of our study was to measure serum 25(OH) Vitamin-D in patients with chronic liver disease with an object to correlate the results with conventional hepatic markers for assessment of severity of the disease. Methods: In this study, we measured serum 25(OH) Vitamin D (Total) along with routine liver function test in 50 patients of CLD of various types, 50 healthy individuals were selected conveniently as controls. Results: We observed a deficient Vitamin D level in all the patients of CLD. Serum Vitamin D level was found to be inverse lyproportional with severity of liver damage and the result is statistically significant. Conclusion: Our study indicates that severity of liver disease is associated with hypovitaminosis D. We observed inverse relationship between hepatic enzyme levels and serum vitamin D concentrations in patients with severe type of CLD. We propose that estimation of vitamin D as a routine mighthelpin diagnostic and prognostic aspect of severe type of chronic liver disease.
Authors and Affiliations
Jyoti Paul, Gora Chand Bhattacharya, Ila Bhattacharjee
Keywords
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