Decreased serum adiponectin is associated with carotid atherosclerotic changes in type 2 diabetes mellitus patients
Journal Title: Medpulse International Journal of Biochemistry - Year 2018, Vol 7, Issue 3
Abstract
Background: Cardiovascular disease is the leading cause of death in world. The early detection of cardiovascular disease and risk identification is paramount to prevent and treat this condition. Even though many risk predictors like lipid profile, early Electrocardiogram changes exist, we need a marker which can predict the occurrence of the cardiovascular events more earlier. Serum Adiponectin is emerging as a risk predictor and a novel biomarker for Coronary vascular disease. Aims: In this study, we investigated the relationship of serum adiponectin levels and carotid intima media thickness in type II diabetic individuals. Materials and Methods: 48 known type II diabetics (aged 35-55 yrs) attending Diabetic OPD on treatment with oral hypoglycemic drugs were taken as study subjects. Anthropometric and metabolic assessments including serum Adiponectin levels were done. B-mode ultrasound imaging of the both common carotid arteries was used to measure common CIMT (Carotid intima-media thickness). Results: CIMT were higher in subjects with hypoadiponectinemia (p<0.013) than subjects with normal adiponectin levels. Serum Adiponectin was negatively associated with age (P<0.05), Conclusion: In diabetic patients, decreased serum adiponectin levels may lead to atherosclerosis of blood vessels and measurement of this can be a good predictor of future vascular events.
Authors and Affiliations
V Hariharan, S Ramya, V C Renju
Keywords
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- EP ID EP442704
- DOI 10.26611/1002735
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