Ischemia modified albumin in early diabetic nephropathy
Journal Title: Medpulse International Journal of Biochemistry - Year 2018, Vol 7, Issue 2
Abstract
Background: Ischemia and hypoxia are observed in diabetic patients in addition to chronic hyperglycemia and intensified oxidative stress. It is reflected by increased markers levels of oxidative protein damage, especially in patients with vascular complications, as well as ischemia−modified albumin (IMA). Objective: To assess the plasma levels of IMA in T2DM patients with early diabetic nephropathy and their relationship with routine markers of kidney disease severity (urinary microalbumin, plasma creatinine concentration) Materials And Methods: Plasma IMA levels were manually determined in 100 patients and 50 healthy people by spectrophotometric Co(II)−albumin binding assay. Micoalbuminuria was detected using turbidimetric method and creatinine using Jaffe’s method in Cobas Autoanalyzer Results: The IMA levels in the diabetic patients were significantly higher than in the healthy controls and increased progressively with the degree of DN. The normoalbuminuria group 1 had the lowest IMA level, which significantly increased with development of microalbuminuria and as nephropathy progressed in group 2 and group 3. There were significant relationships between IMA and microalbuminuria (r = 0.87) Conclusion: This study indicates that the observed increased IMA in T2DM is connected with diabetic nephropathy. Measuring IMA plasma levels provided additional information about nephropathy development and it may be helpful in assessing the severity of oxidative stress, which causes kidney dysfunction at an early stage.
Authors and Affiliations
Mukherjee Brijesh, Sahoo Sibasish
Keywords
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