A study on genotypic frequency of 12-lipoxygenase polymorphisms and 12-HETE levels in type II diabetes

Journal Title: Medpulse International Journal of Biochemistry - Year 2018, Vol 7, Issue 3

Abstract

Background: Diabetes mellitus describes a group of metabolic diseases characterized by a progressive insulin secretory defect due to insulin resistance resulting in high glucose levels in the blood. Approximately 90% of all the cases of diabetes worldwide are type II Diabetes Mellitus where enough insulin is not produced for proper function. Growing body of evidence has suggested that beta cell inflammation and dysfunction play a key role in the pathogenesis of type II diabetes. Obesity and lack of exercise are some of the contributory factors for type II diabetes mellitus. A class of enzymes called lipoxygenases and derived oxidized lipids induces inflammation of beta cells and has been implicated in diabetes development. Studies show that the genetic deletion of 12-lipoxygenase (12-LOX) decreases the activity of 12-LOX and further decrease beta cell inflammation and dysfunction. Hence our main objective was to study the polymorphisms of 12-LOX gene in type II diabetes. Materials and Methods: Study participants included were in the age group of 30-70 years. 30 diagnosed patients of diabetes with the minimum history of 3 years were selected as cases. Equal number of age and sex matched healthy individuals were included in the control group. A detailed clinical history, family history and demographic details were collected from the subjects. Body Mass Index (BMI), HbA1c levels, Plasma 12-Hydroxyeicosatetraeinoic acid (12-HETE) levels and 12-LOX gene polymorphisms were assessed. Results and Conclusion: We observed significant difference in the routine parameters such as Fasting blood sugar (FBS), HbA1c and BMI whereas the 12-HETE levels did not show any significant difference between diabetic and non-diabetic subjects. Polymorphism study revealed varied genotype distribution of G>A and C>T gene clusters but again did not show any significance.

Authors and Affiliations

Suma M Nataraj, Devananda Devegowda, Anisha Mathai, Ankita Mysore Amarbabu, Arpitha Bankenhalli Jayaram, Pushkal Sinduvadi Ramesh, Swetha Kempegowda

Keywords

Related Articles

Correlation between serum PON-1 activity and lipid profile in diabetes mellitus

Background: PON1 has detoxification activity in atherosclerotic processes. Serum PON1 activity has been shown to be reduced in atherogenesis. Thus, estimation of PON activity in diabetes mellitus is being valuable in pre...

Biochemical parameters and its association with quality of life in patients with diabetic foot ulcers

Background: Diabetic foot ulcer (DFU) is a serious complication of Diabetes mellitus (DM) with significant impact on the quality of life(QoL). Various biochemical parameters can play important role in evaluating QoL in D...

Duration of type 2 diabetes mellitus as a threat indicator for the microalbuminuria; A signal for diabetic nephropathy

Background: Diabetes mellitus is one of the major health problem leading to the long term kidney damage and responsible for 30-40% of all chronic kidney diseases. Aim and Objectives: The study was conducted to find the a...

Correlation between thyroid profile and liver function tests in pregnancy

Problem Statement: Liver has a key role in thyroid hormones metabolism and their serum level is very important for normal hepatic function and Bilirubin metabolism. Besides the associations between thyroid and liver dise...

Fasting insulin predicts an insulin resistance: A meta analysis using western countries data

Background: The American Diabetes Association included hemoglobin A1c (HbA1c) as adiagnostic test for diabetes in their 2010 clinical practice recommendations Aims and Objectives: To study Fasting insulin and insulin res...

Download PDF file
  • EP ID EP442662
  • DOI 10.26611/1002733
  • Views 161
  • Downloads 0

How To Cite

Suma M Nataraj, Devananda Devegowda, Anisha Mathai, Ankita Mysore Amarbabu, Arpitha Bankenhalli Jayaram, Pushkal Sinduvadi Ramesh, Swetha Kempegowda (2018). A study on genotypic frequency of 12-lipoxygenase polymorphisms and 12-HETE levels in type II diabetes. Medpulse International Journal of Biochemistry, 7(3), 64-68. https://europub.co.uk/articles/-A-442662