Comparative assessment of side effects of etomidate and propofol: A double blinded study from urban Karnataka
Journal Title: Medpulse International Journal of Anesthesiology - Year 2019, Vol 9, Issue 2
Abstract
Background: Propofol and Etomidate is commonly used in anaesthesia practice. However pain on injection and myoclonus are the most common side effects of this drug. Objectives: To compare the side effects between Etomidate and Propofol. Methodology: In this prospective randomized double blinded study, we studied 60 patients randomly allocated into either group P (propofol group) or to group E (Etomidate group) of 30 each. All patients premedicated with inj. midazolam 0.02mg/kg IV, inj. Fentanyl 2 microgm/kg IV. Group P received propofol infusion at 0.5 mg/kg/hr and group E at 0.05mg/kg/hr until BIS value dropped to 50. Then patients were intubated with vecuronium 0.1mg/kg and anaesthesia maintained according to institutional protocol followed by extubation after adequate recovery. Hemodynamic parameters and side effects during induction were recorded between both groups until the infusion of study drug. Results: So prevalence of myoclonus was found to be 40% in Etomidate group. Prevalence of Thrombophlebitis in etomidate was found to be 13.3%. Proportion of patients experienced pain was more in Propofol group i.e. 36.7% as compared to Etomidate i.e. 20%. (>0.05). 10 patients in Etomidate group experienced nausea i.e. 33.3% as compared to 2 in Propofol group i.e. 6.7%. (<0.05). 3 patients in Etomidate group experienced vomiting i.e. 10% as compared to 1 in Propofol group i.e. 3.3% (>0.05) Conclusion: Myoclonus and Thrombophlebitis was observed in Etomidate group only (<0.05). Propofol causes more pain as compared to Etomidate (>0.05). Propofol causes less nausea (<0.05) and vomiting (<0.05) as compared to Etomidate.
Authors and Affiliations
Ramesh babu, Mohan . , Prashanth Vadigeri, Sunil Kumar, Rajashekar Mudaraddi
Keywords
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- EP ID EP521033
- DOI 10.26611/10159210
- Views 137
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