Comparative Effect of Carbimazole, Citrus sinensis, Glycine Max and Levothyroxine on Blood Glucose Levels and Body Weight Changes
Journal Title: Journal of Pharmaceutical Research International - Year 2014, Vol 4, Issue 2
Abstract
Aims: The role of thyroid hormones as important mediator of glucose metabolism and body weight dynamics had long been established. This study was therefore designed to evaluate the effect of standard thyro-active drugs in comparison to crude nutritional extracts, on blood glucose level and body weight changes. Methodology: Albino wistar rats weighing between 100 - 150g were randomly assigned to seven groups of seven rats each. Group 1 served as control, while groups 2-7 were orally administered Fresh orange juice(FOJ) (1500mg/kg), Fresh soybean(FSB) (0.01mg/kg), levothyroxine (LVT) (0.01mg/kg), carbimazole (Carb) (0.01mg/kg), FSB+LVT and FOJ+Carb respectively once daily for twenty eight days. Weekly weight records were taken and the difference calculated as weight changes. The animals were sacrificed and blood samples collected by cardiac puncture. Serum was obtained by standard procedure and used for blood glucose estimation. Results: Separate treatment with both FOJ and FSB significantly (P<0.05) increased the blood glucose levels and body weight compared to control. Levothyroxine significantly (P<0.05) increased the blood glucose levels but significantly (P<0.05) decreased the body weight compared to the FOJ treated group. Carbimazole significantly (P<0.05) decreased the blood glucose levels compared to the control, FOJ and FSB treated groups. FSB+LVT treatment significantly (P<0.05) decreased the blood glucose levels compared to the LVT group and also significantly (P<0.05) decreased the body weight compared to the control, FOJ and FSB groups. FOJ+Carbimazole combination treatment significantly (P<0.05) decreased the blood glucose levels compared to LVT treatment and also significantly (P<0.05) decreased the body weight compared to the FOJ and FSB groups. FOJ significantly reduced T4 and T3 levels compared to control. FOJ, Carb and FOJ+Carb significantly (p<0.05) reduced T4 level compared to control. Conclusion: The acclaimed antithyroid activity of FOJ and FSB did not appear to directly correlate with that of carbimazole, a standard antithyroid drug, considering their effect on blood glucose level and body weight changes. However their combination treatment with Carb and LVT respectively, showed similar pattern with carbimazole.
Authors and Affiliations
Okon Uduak Akpan, Udobang John Akpan, Ologhaguo Macstephen Adienbo, Ani Elemi John
Keywords
Related Articles
- EP ID EP344296
- DOI 10.9734/BJPR/2014/5665
- Views 106
- Downloads 0
Pharmacist Perceived Barriers to Patient Counseling; A Study in Eastern Region of Saudi Arabia
Background: Pharmaceutical care model (PCM) is the philosophy of practice that includes identifying and resolving medication therapy problems to improve patient outcomes. Patient counseling by a pharmacist is a fundament...
Biocompatible and Biodegradable Chitosan / Clay Nanocomposites as New Carriers for Theophylline Controlled Release
Aims: Carrier polymeric materials based on chitosan and chitosan / montmorillonite crosslinked with glutaraldehyde were prepared and studied for their biocompatibility, nontoxicity, and biodegradability aiming their appl...
Membrane Stability and Antioxidant Activity of Gmelina arborea Seed Extracts and Their Fatty Acid Composition
Aims: In the present study different extracts of seeds of Gmelina arborea were prepared and evaluated their membrane stabilizing and antioxidant effects. The Fatty acid composition was also estimated. Study Design: Fatt...
Transdermal Drug Delivery: Microneedles, Their Fabrication and Current Trends in Delivery Methods
The past few decades have seen a tremendous growth in the use of microneedles in the transdermal delivery of therapeutics. This is due to the several advantages that microneedles offer in the delivery of compo...
TiCl4/nano-sawdust as an Efficient Biocatalyst for the Synthesis of Highly Substituted Dihydro- 2-oxopyrroles as Antimicrobial Agents
Aim: Sawdust nano particles was prepared from the pine wood and applied for the synthesis of TiCl4/nano-sawdust as a readily available, inexpensive, biodegradable and environmentally benign heterogeneous solid acid bioca...