Comparative effect of fixed dose combination of Amlodipine + Bisoprolol versus Amlodipine and Bisoprolol alone on blood pressure in stage-2 essential hypertensive patients
Journal Title: International Journal of Medical Research & Health Sciences (IJMRHS) - Year 2012, Vol 1, Issue 1
Abstract
Background: Employment of low dose combinations of two antihypertensives, with different mode of action has gained acceptance worldwide for the treatment of mild to moderate hypertension. However, most studies in hypertensive disease have focused on monotherapy. The combination therapy in the treatment of hypertension is largely extrapolated from these monotherapy studies. Objectives: To study and compare the effect of amlodipine, bisoprolol and fixed dose combination of amlodipine + bisoprolol on blood pressure in stage-2 essential hypertensive patients. Methods: The present study was carried out in Department of Pharmacology in collaboration with Department of Medicine at Government Medical College and Hospital, Aurangabad. Results and Conclusion : Amlodipine + bisoprolol in fixed dose combination have showed significant blood pressure control in patients of stage-2 essential hypertension and the antihypertensive effect was greater than individual monotherapy study groups.
Authors and Affiliations
Shirure PA| Dept of Pharmacology, GMC, Nanded, Maharashtra, Tadvi NA| Dept. of Pharmacology, KIMS, Narketpally, Andhra Pradesh, Bajait CS| Dept of Pharmacology, GMC, Nagpur, Maharashtra, Baig MS| Dept of Pharmacology, GMC, Aurangabad, Maharashtra, Gade PR| Dept of Pharmacology, MIMSR Medical College, Latur, Maharashtra
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