ACUTE TOXICOLOGICAL EVALUATION OF PET – ETHER EXTRACT OF PORTULACA OLERACEA (LINN.) ON RODENTS
Journal Title: International Journal of Medical Research & Health Sciences (IJMRHS) - Year 2013, Vol 2, Issue 2
Abstract
Introduction: Portulaca oleracea is a common plant used in south Indian culinary; recently there is increase in research publication on various biological activities of the medicinal herb. The safety of the medicinal herb well accounted by its widespread accepted use of natives yet scientific evaluation on the safety of the herb is not reported. Aim To scientifically evaluate the toxicity profile of the pet - ether extract of Portulaca oleracea by standardized methods. Method A 24hour acute toxicity study followed by 14 day sub-acute toxicity study with serum haematological, biochemical and histopathological analysis’s is evaluated in rodents. Result No observable serious side effects are recorded in acute and sub acute toxicity study for 0.5gm/kg and 1gm/kg pet-ether extract of Portulaca oleracea. There are statistically significant rising (p<0.01) in hemoglobin by 13.25%, 15.42% and 15.04% in Portulaca oleracea 0.5gm, 1gm, and 2gm/kg body weight respectively when compared to control 10.56%. Portulaca oleracea 2gm/kg dose administration for 14 days has revealed oxalate crystal deposits in the kidney. CONCLUSION The pet –ether extracts of Portulaca oleracea 0.5gm, 1gm, and 2gm/kg exhibited zero mortality rates in both acute and sub-acute toxicity studies and found to increase haemoglobin, total cholesterol levels in serum which can be seriously evaluated for further research.
Authors and Affiliations
Siva Reddy| Department of Forensic medicine, Sri Venkateshwaraa Medical College Hospital & Research Centre, Ariyur, Pondicherry. PIN - 605 102, India Corresponding author email: padmasivareddy@gmail.com, Somasundaram G| Department of Pharmacology, MGMCR&I, Pilayarkuppam, Puducherry, PIN – 604702, India
Keywords
Related Articles
- EP ID EP10972
- DOI -
- Views 388
- Downloads 21
The survey of the relationship between test anxiety and self-efficacy among the city of Urmia’s medical sciences university students in 2016
The great majority of the students who acquire good marks during the curriculum terms have been found to experience a drop in their final scores at the end of the semester and this can be a result of the high level of a...
Effectiveness of attentional bias modification and cognitive behavioral therapy on the reduction of pain intensity in patients with chronic pain
The aim of the study was to determine the effectiveness of Attentional Bias Modification (ABM) and Cognitive Behavioral Therapy (CBT) on the reduction of pain intensityin patients with chronic pain. This study was a qua...
Post CABG Psychological Disorder: New Update for Surgeons and Nursing Groups
Atherosclerosis a type of arteries’ hardening that is caused by the formation of atheromatous plaque in the vessel wall. CABG is proposed as a standard of care for patients with coronary artery disease. This method be...
Silhouette of substance abuse amongst an adolescent sample group from urban slums of Guwahati metro, North East India
Globally 320 million young people between ages 15-29 years are dying from alcohol related causes. Child line foundation survey report showed that 13.1% of the people involved in drug and substance abuse in India, are a...
Comparison of Mec A Gene in Staphylococcus Aureus Isolated from Children at Time of Admission and Discharge in West of Iran
Staphylococcus aureus (SA) is a species of the genus Staphylococcus that is found everywhere, including in the respiratory tract and on the skin of many adults and children, and that is considered one of the main pathog...