ACUTE TOXICOLOGICAL EVALUATION OF PET – ETHER EXTRACT OF PORTULACA OLERACEA (LINN.) ON RODENTS
Journal Title: International Journal of Medical Research & Health Sciences (IJMRHS) - Year 2013, Vol 2, Issue 2
Abstract
Introduction: Portulaca oleracea is a common plant used in south Indian culinary; recently there is increase in research publication on various biological activities of the medicinal herb. The safety of the medicinal herb well accounted by its widespread accepted use of natives yet scientific evaluation on the safety of the herb is not reported. Aim To scientifically evaluate the toxicity profile of the pet - ether extract of Portulaca oleracea by standardized methods. Method A 24hour acute toxicity study followed by 14 day sub-acute toxicity study with serum haematological, biochemical and histopathological analysis’s is evaluated in rodents. Result No observable serious side effects are recorded in acute and sub acute toxicity study for 0.5gm/kg and 1gm/kg pet-ether extract of Portulaca oleracea. There are statistically significant rising (p<0.01) in hemoglobin by 13.25%, 15.42% and 15.04% in Portulaca oleracea 0.5gm, 1gm, and 2gm/kg body weight respectively when compared to control 10.56%. Portulaca oleracea 2gm/kg dose administration for 14 days has revealed oxalate crystal deposits in the kidney. CONCLUSION The pet –ether extracts of Portulaca oleracea 0.5gm, 1gm, and 2gm/kg exhibited zero mortality rates in both acute and sub-acute toxicity studies and found to increase haemoglobin, total cholesterol levels in serum which can be seriously evaluated for further research.
Authors and Affiliations
Siva Reddy| Department of Forensic medicine, Sri Venkateshwaraa Medical College Hospital & Research Centre, Ariyur, Pondicherry. PIN - 605 102, India Corresponding author email: padmasivareddy@gmail.com, Somasundaram G| Department of Pharmacology, MGMCR&I, Pilayarkuppam, Puducherry, PIN – 604702, India
Keywords
Related Articles
- EP ID EP10972
- DOI -
- Views 365
- Downloads 21
Detection of mecA Gene Associated with Methicillin Resistant Staphylococcus aureus and its Alternatives using Nanoparticles and Chia Seeds
Staphylococcus aureus, a member of the family Micrococcaceae, is a Gram-positive coccus whose cells tend to occur either singly or if dividing cells do not separate, form pairs, tetrads and distinctive irregular “grap...
Cutoff point amniotic fluid index and pregnancy prognosis in the third trimester of pregnancy in Shariati Hospital of Bandar Abbas in 2013-14
Background and purpose of study: Amniotic fluid volume varies according to different stages of fetal growth and its different requirements. Disrupted amniotic fluid volume is associated with an increased risk for the fe...
The frequency of nasal septal deviation and concha bullosa and their relationship with maxillary sinusitis based on CBCT finding
CBCT has facilitated the differential diagnosis due to the lower dose of radiation and higher resolution compared to CTscan. This study examines the frequency of deviated nasal septum, concha bullosa and their relations...
SCREENING OF ANTIBIOTIC RESISTANT GRAM NEGATIVE BACTERIA AND PLASMID PROFILING OF MULTI-DRUG RESISTANT ISOLATES PRESENT IN SEWAGE ASSOCIATED WITH HEALTH CARE CENTERS
Background: Healthcare effluent acts as the store house of harmful infectious agents such as the pathogens and microorganisms possessing multiple drug resistant genes. Potential health risk includes spreading of diseas...
Detection of Outliers in Regression Model for Medical Data
In regression analysis, an outlier is an observation for which the residual is large in magnitude compared to other observations in the data set. The detection of outliers and influential points is an important step of...