Comparative Effect of Two Different Doses of Vitamin D on Diabetic Foot Ulcer and Inflammatory Indices among the Type 2 Diabetic Patients: a Randomized Clinical Trial
Journal Title: Iranian Journal of Diabetes and Obesity - Year 2016, Vol 8, Issue 4
Abstract
Objective: The current study was conducted to compare the effect of 150,000 and 300,000 IU of vitamin D on the healing status of diabetic foot ulcer among the patients with diabetes. Materials and Methods: This randomized clinical trial was carried out on 47 patients with diabetic foot ulcer and vitamin deficiency during four weeks follow-up. The patients were randomly assigned into two groups; group G150 was administered 150000 IU of vitamin D and group G300 was administered 300000 IU of vitamin D. Serum 25-hydroxyvitamin D, ulcer area, fasting blood sugar (FBS), c-reactive protein (CRP), white blood cells (WBC) and erythrocyte sedimentation rate (ESR) were measured in both groups before and after intervention. Results: Serum vitamin D level in both groups was significantly increased compared to the baseline (P<0.01). The mean of serum vitamin D changes were 12.6±5.0 and 18.4±6.4 ng/ml (P=0.001) in G150 and in G300, respectively. The ulcer area was significantly reduced in both groups compared to the baseline (P<0.01).WBC, ESR, FBS and CRP were significantly declined compared to the baseline in both groups. However, the mean changes of serum FBS and CRP levels were found to be significantly different between groups. Discussion: The findings showed administration of 150,000 and 300,000 IU of vitamin D improved the ulcer and vitamin D status and reduced ESR, CRP, WBC and FBS in the patients with diabetic foot ulcer. In addition, the 300,000 IU of vitamin D was significantly more effective than 150,000 IU.
Authors and Affiliations
Hassan Mozaffari-Khosravi, Mohsen Haratian-Arab, Hosein Moein Tavakkoli, Azadeh Nadjarzadeh
Keywords
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