Relation between Malnutrition–Inflammation–Atherosclerosis (MIA complex) in Diabetic Patients with Peritoneal Dialysis

Journal Title: Iranian Journal of Diabetes and Obesity - Year 2016, Vol 7, Issue 4

Abstract

Objective: Atherosclerosis disease, inflammation and malnutrition have strong association with end stage renal disease (ESRD). Diabetes mellitus (DM) is the most commonly ESRD causes. Diabetic nephropathy (DN) could be associated with inflammation. Type 2 diabetic patients with advanced nephropathy show the highest levels of inflammatory markers. This study was designed to determine the association between malnutrition–inflammation–atherosclerosis (MIA complex) in Diabetic patients with peritoneal dialysis. Materials and Methods: Fifty seven diabetic patients on peritoneal dialysis were investigated and demographic variables (age, gender, BMI and dialysis duration), Inflammatory markers (cholesterol, Albumin and CRP) were measured in routine protocol. CIMT (Carotid Intima-Media Thickness) and plaque number were evaluated by B-Mode ultrasonography (7.5 -10 MHZ probe) in supine position. Results: the mean age (Standard deviation) of patients was 51±17.3 years. The mean time on dialysis was 26.12 ±25.42 (range 4–120) months. The mean of IMT was 5.98±1.17 mm and mean of plaques were 1.80±2.01. Results of Analysis of variance (ANOVA) showed that older patients have more carotid plaques (P-Value= 0.000). There was a significant relation between serum albumin and number of plaques (P-Value=0.043). CIMT and number of plaque revealed significant correlation with age, serum albumin and dialysis duration (P<0.05). Conclusion: Our findings showed, in diabetic patients on peritoneal dialysis, carotid atherosclerosis (CIMT and Number of plaque) is associated with some inflammation, malnutrition markers.

Authors and Affiliations

Seid Kazem Razavi Ratki, Reza Nafisi Moghadam

Keywords

Related Articles

The Study of SAD1/UNC-84 Domain Protein 1 in Muscle of Diabetic Male Wistar Rats

Objective: The purpose of this study was to measure the changes of the SUN1 protein levels on soleus muscle in diabetic male wistar rats. Materials and Methods: Twenty male Wistar rats with 10 weeks old and weighing 200-...

The Effect of Oral L-arginine Supplementation on Blood Pressure in Patients with Metabolic Syndrome: A Randomized Clinical Trial

Objective: Hypertension is a common component of metabolic syndrome (MetS). Some studies showed that L-arginine reduced the blood pressure (BP) .Therefore this study was designed to evaluate the effect of L-arginine supp...

Evaluation of the Salivary Total Antioxidant Capacity and Lipid Peroxidation Status in Type 2 Diabetes Mellitus Patients

Objective: Type 2 diabetes mellitus (T2DM) is a multifactorial disorder with various disturbances in biochemical processes such as antioxidant status and lipid peroxidation. The aim of present study was evaluation of the...

The Effect of Four Weeks Continuous Aerobic Training on Liver Transaminases and Glycemic Markers in Women with Type II Diabetes

Objective: Fatty liver disease is one of the most common diseases in women with type II diabetes. While regular exercise can decrease the complication of this disease, it was not clearly identified. The aim of this study...

The Effects of Endurance Training with Genistein on ICAM-1, VCAM-1, and CRP of Diabetic Rats

Objective: The purpose of this study was to investigate the effects of endurance training accompany with taking genistein on Intercellular Adhesion Molecule 1 (ICAM-1), vascular cell adhesion molecule 1 (VCAM-1), and C-r...

Download PDF file
  • EP ID EP634711
  • DOI -
  • Views 44
  • Downloads 0

How To Cite

Seid Kazem Razavi Ratki, Reza Nafisi Moghadam (2016). Relation between Malnutrition–Inflammation–Atherosclerosis (MIA complex) in Diabetic Patients with Peritoneal Dialysis. Iranian Journal of Diabetes and Obesity, 7(4), 177-181. https://europub.co.uk/articles/-A-634711