The Effect of Oral L-arginine Supplementation on Blood Pressure in Patients with Metabolic Syndrome: A Randomized Clinical Trial
Journal Title: Iranian Journal of Diabetes and Obesity - Year 2018, Vol 10, Issue 1
Abstract
Objective: Hypertension is a common component of metabolic syndrome (MetS). Some studies showed that L-arginine reduced the blood pressure (BP) .Therefore this study was designed to evaluate the effect of L-arginine supplementation on BP in MetS. Materials and Methods: In this randomized, double-blind, placebo-controlled trials, 60 patients with MetS were randomly divided into two groups: the L-arginine-supplemented group (AG), who received 5 gr of L-arginine daily and placebo group (PG). Systolic blood pressure (SBP), diastolic blood pressure (DBP), mean arterial pressure (MAP), pulse pressure (PP) were measured before and after the intervention and compared. Results: At the end of the study in the AG significant reductions were observed in the SBP, DBP and MAP (P-value:0.001).The comparison of changes in variables between the AG and PG indicated that in the AG, patients had a significantly greater decrease in the SBP (-11.25±10.93 vs. -2.67±6.15 mmHg: P-value:0.001), DBP(-5.71±7.16 vs. -1.25±7.02 mmHg: p-value: 0.02) and MAP (-7.55±5.61 vs.-1.72±5.16 mmHg, P-value: 0.001). The PP decreased in both groups but a significant decrease compared with baseline in the AG was observed (-5.53±13.83 vs. -1.42±9.21 mmHg: P-value: 0.19). Conclusion: The findings of the present study showed that 5 gr/d L- arginine supplementation for 12 weeks in MetS resulted in significant decrease in the SBP, DBP and MAP but had no significant effect on the PP
Authors and Affiliations
Davood Bahrami, Hassan Mozaffari Khosravi
Keywords
Related Articles
- EP ID EP636072
- DOI -
- Views 47
- Downloads 0
The Effect of Swimming Training with Cinnamon Extract on Hematological Factors in Diabetic Rats
Objective: Diabetes is one of the most common metabolic diseases which can lead to cardiovascular disorders. The purpose of this study was to evaluate the effect of swimming training with cinnamon extract on hematologica...
The Effect of Endurance Exercise and Adenosine Consumption on UCP-1 Gene Expression in the Visceral Adipose Tissue of Obese Male Rats
Objective: Reducing white adipose tissue is an important strategy for treatment of obesity and its related metabolic disorders. The purpose of this study was to determine the effect of endurance exercise and adenosine co...
The Study of SAD1/UNC-84 Domain Protein 1 in Muscle of Diabetic Male Wistar Rats
Objective: The purpose of this study was to measure the changes of the SUN1 protein levels on soleus muscle in diabetic male wistar rats. Materials and Methods: Twenty male Wistar rats with 10 weeks old and weighing 200-...
The Effect of 6 Weeks Resistance Training and High-Intensity Interval Training on Glut-4 Gene Expression of Diabetic Rats
Objective: GLUT4 glucose transporter content and glucose transport capacity are closely correlated in muscle. The purpose of current study was to evaluate the effect of 6 weeks of resistance training and High-Intensity I...
The Association between the Components and Features of Metabolic Syndrome in Patients with Psoriasis and Psoriatic Arthritis
Objective: Psoriasis (Pso) is associated with an increased risk of cardiovascular involvement. Metabolic syndrome (MetS) includes a group of classic cardiovascular risk factors with pro-inflammatory condition. The aim of...