Effect of 12 Weeks Aerobic Training on FOXO1 Gene Expression in Pancreatic Tissue of Type 2 Diabetes Wistar Rats
Journal Title: Iranian Journal of Diabetes and Obesity - Year 2018, Vol 10, Issue 4
Abstract
Objective: Exercise as a non-pharmacological treatment plays an important role in regulating and reducing the inflammatory cytokine associated with beta cell function. Genetics is one of the most important and effective factors in the incidence of diabetes, in most cases. The present study aims to explain the effect of 12 weeks aerobic training on FOXO1 expression in pancreatic tissue, insulin and blood glucose levels in male wistar rats with type 2 diabetes mellitus. Materials and Methods: In this study, 16 male wistar rats were divided into diabetic control and diabetic training groups. The two groups were diabetic with nicotine amide and streptozotocin injections and the training group did aerobic exercises for treadmill for 12 weeks. Results: The results of the study showed a significant increase in FOXO1 expression after 12 weeks of aerobic training (P-value: 0.027), which resulted in a significant decrease in blood glucose concentration (P-value: 0.0001). Conclusion: The induction of type 2 diabetes leads to a reduction in the expression of FOXO1 gene in the tissues of the pancreas in experimental rats, which is associated with a decrease in serum levels of insulin and an increase in blood glucose levels. On the other hand, 12 weeks of aerobic training of 5 sessions per week leads to a significant increase in the expression of FOXO1 gene, with decreasing glucose and increased serum insulin in the pancreatic tissue of diabetic rats.
Authors and Affiliations
Saqqa Farajtabar Behrestaq, Nader Shakeri, Farshad Ghazalian, Hojatollah Nikbakht
Keywords
Related Articles
- EP ID EP636048
- DOI -
- Views 56
- Downloads 0
Comparison of Experiential Avoidance, Explicit and Implicit Attraction Beliefs in Obese and Normal Weight Females
Objective: The aim of this study was to compare the experiential avoidance, explicit and implicit attraction beliefs in obese and normal body mass index (BMI) females. Materials and Methods: This was an analytic cross s...
Whey Protein Supplementation is Associated with Antioxidant Markers Following Severe Eccentric Contractions in Obesity
Objective: Intense muscle contractions are associated with oxidative stress and immune system deficiency, especially in the presence of obesity. This study aimed to determine the effect of whey protein supplementation fo...
Does Monosodium Glutamate Induce Obesity in Female Mice?
Objective: Female metabolism is highly responding towards diet associated changes. Monosodium glutamate is a popular flavor enhancer, which is widely used to develop umami taste. Young female generation nowadays deals wi...
Genetics of Type 2 Diabetes- A Review Article
Objective: Type 2 diabetes (T2D) as a complex disease is the result of genetically heterogeneous factors and environmental issues interaction. Linkage and small-scale candidate gene studies were successful in identificat...
A Review on Relationship between Type II Diabetes and Cognitive Impairment
The association between diabetes and cognitive impairment is controversial. This systematic review examines the relationship of Cognitive Impairment in people with diabetes mellitus. The incidence of “Cognitive Impairmen...