COMPARATIVE EFFICIENCY OF ACETYLCALCYTEIN APPLICATION IN ORAL AND INHALATION FORM WITH THE HELP OF NEBULAISER IN PATIENTS WITH COPD
Journal Title: Астма и Аллергия - Year 2019, Vol 1, Issue 1
Abstract
Aims. To determine the efficacy and safety of nebulized inhalation of acetylcysteine compared with its oral administration in patients with chronic obstructive pulmonary disease (COPD). Materials and methods. The study included 31 patients, two groups of patients were formed. In the first of them (n = 13) patients took acetylcysteine orally, in the second (n = 18) — by inhalation with a nebulizer for 10 days with stable basic therapy. To assess the severity of symptoms and the effectiveness of treatment, data from validated questionnaires (CAT, mMRC, CCQ) were analyzed, theseverity of day and night cough was assessed on a scale, spirometry and sputum analysis were performed. Results. Patients who received acetylcysteine orally showed a significant improvement in the condition according to the results of the CCQ questionnaire (a decrease by 15.1 %, p < 0.04). According to other methods of diagnostic no significant dynamics was obtained. In the group of patients who received acetylcysteine inhalation, there were significant positive changes in the results of the CAT question-naire (a decrease by 16.8 % compared with the initial level) and a decrease in the symptoms of nocturnal cough (by 36.4 %). In this case, the score according to mMRC, CCQ, the symptoms of daily cough did not change significantly. A decrease in the manifestations ofbronchial obstruction was recorded — an increase in the mean forced expiratory volume in one second (FEV1) value by 10 % (p = 0.01) and decrease of leukocyte count in sputum was obtained. No significant changes of FEV1 after first oral or nebulized exposure of acetyl-cysteine were obtained. Conclusions. Inhalation use of acetylcysteine for 10 days has a wider range of effects on the manifestations of the disease compared with oral administration of the drug in the same dose in patients with COPD without exacerbation but in the presence of sputum. Tolerability of acetylcysteine in both cases of its use is satisfactory, side effects develop rarely.
Authors and Affiliations
O. B. Iaremenko, N. M. Kuzmenkо, G. L. Gumeniuк, D. V. Dobriansky, R. I. Ilnytskyi, O. I. Magas
Keywords
Related Articles
- EP ID EP536224
- DOI 10.31655/2307-3373-2019-1-15-21
- Views 115
- Downloads 0
MANAGEMENT OF PATIENTS WITH ACUTE — TOXICO-ALLERGIC REACTION: ANALYSIS OF CLINICAL EXPERIENCE WITH PRESENTATION OF A SERIOUS CLINICAL CASE
The article summarizes data on the etiology, pathogenesis and clinical manifestations of acute toxico-allergic reactions (ATAR). The analysis of the management of patients with this pathology in the Dnipro Allergological...
Usage of medical thermography to evaluate the results of skin prick testing of patients with allergic rhinitis
Метою дослідження було вивчення аспектів використання медичної термографії для оцінки результатів шкірного тестування розчинами алергенів у пацієнтів з алергічним ринітом у порівнянні з імуноблотингом. Матеріали та...
EFFICIENCY OF THE BASIC THERAPY OF PERSISTENT BRONCHIAL ASTHMA AND THE WAYS OF ITS PERSONIFIED OPTIMIZATION IN GENOTYPIC VARIABLES IN CHILDREN
The efficacy of preventive therapy for bronchial asthma was analyzed among 136 children and influencing factors were determined. The technology of personified phenotype-associated baseline therapy for bronchial asthma in...
SPELEOTHERAPY, HALOTHERAPY, HALOAEROSOLTHERAPY: DEFINITIONS, MECHANISMS OF INFLUENCE, PERSPECTIVES OF USAGE (part II)
Objective of the study is to carry out an analysis of current developments of treatment methods using rock salt or sodium chloride solutions in conditions on the surface on the earth and to evaluate their effectiveness,...
COMPARATIVE EFFECTIVENESS OF APPLICATION OF ACETYLCYSTEIN IN PERORAL AND INHALATION FORM FOR NEBULIZER THERAPY IN PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE
Purpose of the study: to research the dynamics of the sensitization structure in children with bronchial asthma, living in Lviv, in during 5 years (2012-2016 years) and to analyze its age characteristics. Materials and...