Comparative evaluation of FNAC, core needle biopsy and excisional biopsy in subtyping of breast lesions
Journal Title: Pathology Update: Tropical Journal of Pathology and Microbiology - Year 2016, Vol 2, Issue 1
Abstract
Background: Although available literature on Fine needle aspiration cytology (FNAC) and core needle biopsy (CNB) in breast lesions are enormous but studies regarding the comparison of CNB and FNAC in palpable breast lumps within the same patients are very few in eastern part of Uttar Pradesh (Gorakhpur region).Therefore, the present study has been undertaken to evaluate the diagnostic utility of CNB over FNAC and to compare the two with their histopathological examination as an gold standard. Material and Methods: 68 patients with palpable breast lumps were subjected to FNAC and CNB simultaneously and their findings are correlated with their histopathology. Smears were stained by H&E, MGG and Papanicolau stains and reported using Standard National Health Service Breast Screening Programmes (NHSPSB) guidelines. Results: On comparing various parameters for FNAC and CNB shows absolute sensitivity (84.6% vs89.7%), specificity (72.4% vs 96.5%), PPV for C4/B4 (66.6% vs 100%), PPV for C3/B3(14.28% vs 0%), FNR (2.56%VS 0%), inadequate FNAC/B1 for cancer(00% vs 2.5%),suspicious rate(19.1% vs 4.4%) and diagnostic accuracy (79.4% vs 92.6%).On analyzing Z values of all parameters it was found to be statistically significant in specificity (Z=2.56;p<0.01), suspicious rate (Z=27;p<0.01) and diagnostic accuracy (Z=2.45;p<0.01). Conclusion: CNB was more specific than FNAC in correctly typing breast lesions and avoids unnecessary surgical management. It can be used as an alternative to open biopsy for specific diagnosis.
Authors and Affiliations
Mitra Shaila K, Rai Rajesh, Misra Rajiv K, Shilpa Vahikar, Singhal Pallavi
Evaluation of phenotypic methods for rapid detection of Methicillin resistant Staphylococcus aureus in a tertiary care hospital
Introduction: MRSA, an important pathogen causing nosocomial and community acquired infections, has posed a serious therapeutic challenge. A faster, cost effective method detecting MRSA is of utmost necessity. Objective:...
Prevalence and diagnosis of bacterial Vaginosis in tertiary care teaching hospital
Introduction: Bacterial vaginosis is the most common cause of vaginal discharge among women in reproductive age. The normal flora of the vagina varies from person to person, but lactobacilli are usually the preponderant...
Comparative evaluation of bivalent malaria rapid diagnostic tests versus traditional microscopy method in assessment of malaria in blood donors at a tertiary care teaching hospital and regional blood transfusion centre in central India
Background: Global malaria control efforts are based on 2 broad components: vector control and improved diagnosis and treatment of patients with clinical malaria. Until recently, conventional diagnosis of malaria has bee...
Pathological differences between clinically suspected and unsuspected gallbladder carcinoma: A 5- year retrospective study
Introduction: Gallbladder carcinoma frequently presents as incidental finding in routine cholecystectomy specimens operated for gallstone diseases. The reason behind unrecognition of these tumors pre and intraoperatively...
Cutaneous metastasis: Indicators of internal malignancy diagnosed on fine needle aspiration cytology
Introduction: Cutaneous metastases (CM) from various malignancies are uncommon with incidence of 0.8-4% and indicate disseminated disease with poor outcome. Metastatic adenocarcinoma to the skin occurs from gastro-intest...