Comparative Evaluation of Intravenous Dexmedetomidine and Sublingual Nitroglycerin Spray to Attenuate Hemodynamic Response to Laryngoscopy and Intubation
Journal Title: INTERNATIONAL JOURNAL OF SCIENTIFIC STUDY - Year 2018, Vol 5, Issue 11
Abstract
Introduction: Laryngoscopy and intubation produce hemodynamic response due to increase in sympathetic and sympathoadrenal activity which manifest as increase in blood pressure and heart rate (HR). Objective: This study was conducted to compare the effectiveness of intravenous (i.v) dexmedetomidine and sublingual nitroglycerin spray in attenuating the pressor response associated with laryngoscopy and intubation. Materials and Methods: The study was carried out on 90 patients belonging to American Society of Anesthesiologists Grade I and II, aged 18–60 years, including either gender, scheduled for elective surgical procedure under general anesthesia. Results: Systolic blood pressure, diastolic blood pressure, mean arterial pressure, and HR rise in all three groups. However, this rise was significantly less in dexmedetomidine group as compared to control and nitroglycerin group. Conclusion: Dexmedetomidine (0.5 mcg/kg body weight i.v) is more effective for attenuation of hemodynamic response to laryngoscopy and intubation without undesired side effects and complications as compared to nitroglycerin spray.
Authors and Affiliations
Mahendra Pal Singh, Avtar Singh Yadav, Sudhakar Dwivedi, Alok Pratap Singh, Rajiv Dwivedi
Keywords
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