A Prospective, Randomized Study Comparing Bupivacaine and Levobupivacaine through Ultrasound-guided Supraclavicular Block in Patients Undergoing Elective Upper Limb Surgeries
Journal Title: INTERNATIONAL JOURNAL OF SCIENTIFIC STUDY - Year 2018, Vol 5, Issue 12
Abstract
Introduction: Levobupivacaine is a pure S-enantiomer of bupivacaine, and it has similar anesthetic profile with racemic bupivacaine but reduced toxic potential. We conduct the present study to evaluate and compare the intraoperative hemodynamics and onset and duration of sensory and motor blockade. Aim: This study aims to compare ultrasound-guided supraclavicular block using bupivacaine or levobupivacaine in patients undergoing elective upper limb surgery. Methods: After clearance from ethics committee, single-blinded randomized study carried out on ASA-PS І and ІІ patients, undergoing elective upper limb surgeries under supraclavicular block, was randomly assigned two groups Group A - supraclavicular block with 0.5% bupivacaine (0.4 ml/kg) and Group B - supraclavicular block with 0.5% levobupivacaine (0.4 ml/kg). Results: The duration of sensory and motor blockade was prolonged with levobupivacaine. The onset of sensory and motor blockade and intraoperative hemodynamics was same as bupivacaine. Complete failure and toxicity were not reported in both groups. Conclusion: Levobupivacaine is safer and longer acting local anesthetic and its clinical profile is similar to racemic bupivacaine with reduced toxicity.
Authors and Affiliations
A Rajendran, J Venkateswaran, M Gobinath, Heber Anandan
Keywords
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