Fenticonazole Nitrate - A Symptomatic Approach to Vulvovaginal Infection
Journal Title: INTERNATIONAL JOURNAL OF SCIENTIFIC STUDY - Year 2017, Vol 5, Issue 5
Abstract
Abnormal vaginal discharge is a characteristic feature of vulvovaginal infections (VVI). It affects women of reproductive age group worldwide. The most common documented causes of symptomatic vaginal discharge include bacterial vaginosis, followed by vulvovaginal candidiasis and trichomoniasis. The relapse and recurrence rates are increasing due to the use of complex regimens with long treatment duration. Fenticonazole nitrate is an imidazole derivative with a broad spectrum of antimycotic activity against dermatophytes and yeasts in vitro and clinical studies. Fenticonazole has also shown to exhibit antibacterial action against bacteria commonly associated with superficial fungal and vaginal infections and anti-parasitic action against the protozoan Trichomonas vaginalis with high cure rates and good safety and tolerability with low relapse rates. Fenticonazole shows unique multimodal action against Candida species by Inhibiting of secretary aspartate protenase thereby preventing the growth, adherence, and penetration of Candida sp. including N-acetylcysteine leading to clinically significant reduction in the relapse rate. Similarly, fenticonazole inhibits the growth of bacterial (Gardenella vaginalis) and Protozoan (Trichomonas sp.) by inhibition of pyruvate oxido reductase enzyme responsible for cell division or replication. Clinical evidences have shown that fenticonazole does not have any teratogenic effects and has been suggested to be used in high-risk cases from second trimester onward. Fenticonazole is a differentiated imidazole derivative that offers simplistic solution for syndromic approach to VVI infections.
Authors and Affiliations
M S Nanavati, P Bhattacharji, K Krishnaprasad
Keywords
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