Retrospective Cohort Study Analyzing Clinical Utility of Cefpodoxime-ofloxacin Combination in Patients with Community-acquired Infection at Different Outpatient Setting across India
Journal Title: INTERNATIONAL JOURNAL OF SCIENTIFIC STUDY - Year 2017, Vol 5, Issue 1
Abstract
Background: In India, the infectious disease burden is among the highest in the world, and recent World Health Organization report showed the inappropriate and irrational use of antimicrobial agents against many diseases, which led to increase in the development of antimicrobial resistance. Third generation cephalosporins offer increased stability to β-lactamases and an extended spectrum of antibacterial activities, including Gram-positive and Gram-negative pathogen with low minimum inhibitory concentration against sensitive and resistance strain. Fluoroquinolones, a broad spectrum antibiotic, are widely regarded as the most effective drug for the treatment of community-acquired infection. Similarly, the need of broad spectrum antibiotics alone or in combination has been well highlighted in real-world setting due to overlapping symptom and limitation of available diagnostic technique. Objective: The objective of this study is to evaluate the prescription of patients who were prescribed cefpodoxime-ofloxacin combination. Materials and Methods: Retrospective cohort study conducted among 155 outpatient centers across India that analyzed prescriptions where the fixed-dose combination (FDC) of cefpodoxime and ofloxacin in the month of June-August 2015 was prescribed. Results: Totally, 6274 study participants were included in the study, of which 58% were male, and 35% were female, the average age was 36.6 years (range 10-80 years). Typhoid (90%) was the most common indication for which the FDC was prescribed followed by urinary tract infection (UTI) (9%) and acute gastroenteritis (1%). Follow-up data of 85.6% participants were recorded, of which 46.6% has defervescence within 5 days. Cefpodoxime (200 mg)-clavulanic acid (200 mg) was prescribed for 7-14 days in typhoid fever, for 3 days in UTI and for 7 days in acute gastroenteritis. Diarrhea (0.1%) was the most common adverse effect noted which was mild in intensity and was managed symptomatically. There were no serious adverse events recorded. Conclusion: Cefpodoxime-clavulanic acid combination is clinically feasible option for uncomplicated enteric fever, UTI, and AGE.
Authors and Affiliations
Sandesh S Agrawal
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