Comparative evaluation of pancytopenia/bicytopenia in adult and pediatric population in a tertiary care centre through hematological parameters and bone marrow studies
Journal Title: IP Journal of Diagnostic Pathology and Oncology - Year 2018, Vol 3, Issue 4
Abstract
Introduction Pancytopeniabicytopenia is not a disease per se rather a spectrum of changes pertaining to reduction in cell numbers Its presentation as well as causes are diverse in adult and pediatric population It is imperative to evaluate the causes of pancytopeniabicytopenia in adults and pediatric subjects as well as to understand the significant differences in their etiology and manifestations Aims and objectives Comparative evaluation of pancytopeniabicytopenia in adult and pediatric patients through hematological parameters and bone marrow studiesMaterials and Methods In this study 80 adult and 40 pediatric patients of pancytopeniabicytopenia were evaluated Detailed history examination Hb TLC platelet count MCV PBS examination Bone marrow studies were performed Statistical analysis was done using oneway anova Result The commonest presenting age in children was between 1216 years of age and 1940 years in adults Male to female ratio in adults was 1941 while that of pediatric patients was 1074 On bone marrow examination most common cause of pancytopeniabicytopenia among pediatric subjects was aplastic anemia 325 followed by megaloblastic anemia20 acute leukemia 175 erythroid hyperplasia 15 Megaloblastic anemia was the commonest cause of pancytopeniabicytopenia among adult cases 375 followed by erythroid hyperplasia 20 and aplastic anemia 10Conclusion Our study concludes that there is statistically significant difference between the values of Hb TLC Platelet and MCV among adult and pediatric patients of pancytopenia implying that these hematologic parameters vary with respect to mean values and range between the two groups We also conclude nutritional deficiency to be a common cause of pancytopenia in both the age groupsKeywords Aplastic anemia Megaloblastic anemia Pancytopenia
Authors and Affiliations
Pooja Agarwal, Asbah Shams, Arpita Joshi, Prashant Prakash
Keywords
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- EP ID EP482792
- DOI 10.18231/2581-3706.2018.0059
- Views 99
- Downloads 0
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