Comparative evaluation of serum CA 125 in oral submucous fibrosis, oral squamous cell carcinoma and healthy controls: A chemiluminescence immunoassay study.
Journal Title: International Journal of Dental Science and Innovative Research (IJDSIR) - Year 2019, Vol 2, Issue 3
Abstract
Cancer Antigen 125 (CA 125) is also known as mucin 16 or MUC16. It is a glycoprotein present on the surface of normal cells. It appears to be involved in various biological processes including epithelial mesenchymal transition during carcinogenesis. Serum level of CA 125 is utilised to assess the response towards chemotherapy in ovarian carcinoma. The same has also been investigated in other malignancies. Earlier, level of CA 125 has been investigated in saliva in oral squamous cell carcinoma (OSCC) cases. No researches have been conducted so far investigating the serum level of CA 125 in OSCC and potential malignant disorders of oral mucosa. Oral submucous fibrosis (OSF) is a high-risk potential malignant disorder of oral mucosa with numerous systemic alterations. Thus, this study was aimed at investigating serum levels of CA 125 in OSF and OSCC cases. It is a comparative study including three groups viz. group 1 – Patients suffering from OSF, group 2 – Patients suffering from OSCC and group 3 – healthy controls. In each case the serum CA 125 was assessed with chemiluminescence assay. The results obtained were subjected to appropriate statistical methods. We conclude that serum CA 125 may elevate as the normal oral mucosa progresses to the premalignant or a malignant one.
Authors and Affiliations
Arpan K. Shah
Keywords
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