Comparative Studies of the Effect of Sphenocentrum jollyanum Pierre on High Fat and High Carbohydrate Diet Induced Obesity in Rats
Journal Title: Journal of Pharmaceutical Research International - Year 2014, Vol 4, Issue 12
Abstract
Aim: The aim of this study was to compare the effect of ethanolic extract of Sphenocentrum jollyanum on high fat and high carbohydrate diet induced obesity in male wistar rats. Methodology: 30 male wistar rats used for this study were divided into 5 groups of 6 rats each. Group 1 was fed the normal pellet diet (NPD), Group 2 and 3 were fed with high fat diet (HFD), Group 4 and 5 were with fed high carbohydrate diet (HCD) and all groups had free access to diets and water ad libitum for 18 weeks. Treatment with 500mg/kg b.w ethanolic extract of S. jollyanum for Group 3 and 5 started in the 14th week, that is, at the end of obesity induction and lasted for another four weeks. The extract was suspended in normal saline and administered orally to the rats using a gavage tube. Thereafter, the food intake, body weight, total fat mass, adiposity index, total cholesterol, triglycerides, high density lipoprotein cholesterol, very low density lipoprotein cholesterol, low density lipoprotein cholesterol, creatine kinase, lactate dehydrogenase, glucose, insulin and leptin were measured. Results: The results showed that feeding with HFD and HCD significantly increased (p<0.05) body weight, total fat mass, adiposity index, total cholesterol (TC), triglycerides (TG), very density low cholesterol (VDL-C), low density low cholesterol (LDL-C), creatine kinanse (CK) activity, lactate dehydrogenase (LDH), glucose, insulin and leptin levels. The ethanolic extract of S. jollyanum significantly decreased total fat mass, adiposity index, TC, TG, VDL-C, LDL-C, CK activity, LDH, glucose and leptin levels in the HFD group. While among the HCD group, S. jollyanum significantly decreased total fat mass, adiposity index and CK activity. Conclusion: The high fat and high carbohydrate diet induced obesity in the wistar rats and the decrease in the lipid profile, heart biomarkers, glucose and leptin by ethanolic extract of S. jollyanum shows that the plant might possess anti-obesity effect.
Authors and Affiliations
Gabriel O. Anyanwu
Keywords
Related Articles
- EP ID EP344597
- DOI 10.9734/BJPR/2014/10463
- Views 72
- Downloads 0
Antidiabetic Activity of Different Fractions of Ethanolic Extract of Dactyloctenium aegyptium in Streptozotocin Induced Diabetic Rats
Aims: The present study was aimed to evaluate the antidiabetic effect of n-hexane, Chloroform, Ethyl acetate and Methanolic fractions from ethanolic extract of Dactyloctenium aegyptium in streptozotocin induced diabetic...
Cytotoxic Effect of Lingzhi Extracts on Gefitinib-resitant Lung Cancer Cells
Aims: The present study was carried out to investigate the cytotoxicity of extracts from Ganoderma and Amauroderma lingzhi species collected in Tay Nguyen, Vietnam. Methods: Mushroom samples were extracted by methanol an...
Barriers of Medication Adherence and Health Outcomes
Medication adherence is a worldwide health care problem. Medication adherence refers to whether patients take medication as prescribed by the healthcare provider. Increasing medication adherence may have a great impact o...
Evaluation, Formulation and Optimization Study of Myrrh (Commiphora myrrha) Resin as Rate Controlling Excipient in Sustained Release Matrix Tablets of Theophylline
Aims: To investigate myrrh (Commiphora myrrha) resin as a rate controlling excipient in sustained release matrix tablets of theophylline, and to optimize formulation and process variables of the tablet preparation using...
Strategies for the Microbiological Testing of Cosmetic Gels
Background: Official methods for the microbiological testing of cosmetics are available; evidence is required for the suitability of procedure employed particularly while dealing with thick or viscous preparations such a...