Comparative Study between Dexmedetomidine and Lignocaine
Journal Title: Scholars Journal of Applied Medical Sciences - Year 2018, Vol 6, Issue 6
Abstract
Abstract: During induction of general anesthesia hypertension and tachycardia caused by tracheal intubation may lead to cardiac ischemia and arrythymias. Therefore, maintenance of stable haemodynamic parameters during endotracheal intubation under general anaesthesia is crucial to ensure adequate coronary perfusion and prevention of acute rise of blood pressure. To study the hemodynamic response to endotracheal intubation with the new α2 agonist dexmedetomidine, This study was carried out in Yashoda Hospital, Hyderabad. A sample size of 60 patients was selected using random sampling 60 patients aged 18 to 60 yrs, belonging to ASA I and II, were included in the study and they were randomly allocated into 2 groups of n=30 each. Group I received lignocaine 1.5mg/kg iv 3min before induction. Group II received 1mcg/kg iv in 100 ml NS over 15 min. before induction.HR, SBP were recorded pre-operatively, 30 sec after intubation, 1 min after intubation , 3min after intubation & 5min after intubation .RPP derived from HR & SBP method. Patient was allocated in one of the group. After Premedication anaesthesia was induced with inj. Thiopentone 5 mg/kg body wt and endotracheal intubation was facilitated with succinylcholine 1.5 mg/kg body wt administered one minute prior to laryngoscopy and intubation. Laryngoscopy was performed by the experienced anaesthetist who was blinded to the groups. Statistically there was no significant difference in two groups regarding the age (p=0.39001) sex (p=0.17) and weight (p=0.33939). In this study, we observed that the increase in the HR at 1 minute after intubation in compared to basal value was statistically significant (p = 0.01439* ) in dexmedetomidine group (group 2) but it was less then lignocaine group and it came to base line dramatically. we observed that the decrease in SBP observed at 1 minute and 3 min after intubation with dexmedetomidine when compared with basal value and lignocaine was statistically significant (p < 0.0000***) and (p=0.00004*** ) respectively. The decrease in RPP at 1 minute & 3 minute after intubation with dexmedetomidine when compared with the basal value and lignocaine was statistically significant (p =0.0000***) & (p=0.01209*) respectively. Need for rescue analgesia did not arise when dexmedetomidine was added (group I) for performing endotracheal intubation, whereas 16% of patients needed rescue analgesia in lignocaine group due to acute increase in SBP.
Authors and Affiliations
Dr. Amarender Reddy Dumbala, Dr. Nanda Kumar Murari
Keywords
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