COMPARATIVE STUDY BETWEEN INTRAVENOUS DEXAMETHASONE VERSUS KETAMINE GARGLE VERSUS INTRAVENOUS DEXAMETHASONE COMBINED WITH KETAMINE GARGLE FOR EVALUATION OF POST-OPERATIVE SORE THROAT AND HOARSENESS IN MIDDLE EAR SURGERY
Journal Title: Journal of Evolution of Medical and Dental Sciences - Year 2018, Vol 7, Issue 13
Abstract
BACKGROUND Endotracheal intubation is the common cause of trauma to the airway mucosa, resulting in post-operative sore throat (POST) and hoarseness. This study was done to evaluate and compare the effectiveness of prophylactically used dexamethasone-ketamine combination compared with IV dexamethasone/ ketamine-gargle alone in POST and hoarseness in patients undergoing elective middle ear surgery receiving general anaesthesia with endotracheal intubation. MATERIALS AND METHODS This was a prospective, randomised, placebo-controlled and double-blinded clinical study, in which 80 patients (as per convenience as there are 4 groups in my study and availability of patients who meet with the study criteria) aged (16 - 45 yrs.). ASA grade I and II were posted for middle-ear surgery. They were randomly assigned with informed consent into 4 groups (n= 20); Group K: gargled 40 mg ketamine in 30 mL NS for 30 sec; Group D: gargled 30 mL normal saline for 30 sec, received 0.2 mg/kg IV dexamethasone, Group KD: gargled 40 mg ketamine in 30 mL NS for 30 sec and received 0.2 mg/kg IV dexamethasone and Group P: gargled 3 mL NS for 30s, received IV NS (all measures were done 5 mins before induction. POST and hoarseness were graded post-operatively at 0, 1, 6, 12 and 24 hrs.). RESULTS The incidence and severity of POST were significantly lower in Group KD compared with other groups at all times during 24 hrs. post-operatively. Also, the incidence and severity of hoarseness were significantly lower in each one of Groups of KD, K and D compared with Group P. But no significant differences between Groups KD with Group K and Group D. Most of the patients of Group P suffered from POST and hoarseness. CONCLUSION For reducing incidence and severity of POST and hoarseness, administration of ketamine-gargle combined with IV dexamethasone was more effective than using each of these drugs alone at all times after extubation
Authors and Affiliations
Surendra K. Raikwar, Rajkumar Ahirwal, Sweety Bhola
Keywords
Related Articles
- EP ID EP412243
- DOI 10.14260/jemds/2018/370
- Views 89
- Downloads 0
HISTOPATHOLOGICAL STUDY OF OVARIAN TUMORS IN PAEDIATRIC AGE GROUP.
Ovarian tumors are rare in children and constitute 1% of all childhood malignancies and 8% of abdominal tumors. Large cysts and those complicated by torsion make their presence clear by their symptomatology. Ho...
SPECTRUM OF APPENDICEAL LESIONS IN A TERTIARY REFERRAL CENTRE FOR A PERIOD OF ONE YEAR
BACKGROUND Non neoplastic lesions of appendix outnumber the neoplastic counterparts and appendicitis is the frequently encountered lesion in day to day clinical practice. Both non-neoplastic and neoplastic lesions of app...
COMPARATIVE STUDY OF THORACIC PARAVERTEBRAL BLOCK AND GENERAL ANAESTHESIA FOR POST OPERATIVE ANALGESIA IN ELECTIVE BREAST SURGERY
[b]BACKGROUND[/b]: this randomised control trial is to evaluate unilateral paravertebral block in elective breast surgery in comparison with general anaesthesia [b]METHODS[/b]: 106 patients of breast surgery were rando...
USE OF ECG AND OTHER CLINICAL VARIABLES FOR DETECTING PULMONARY HYPERTENSION IN COPD PATIENTS- A CROSS-SECTIONAL OBSERVATIONAL STUDY
BACKGROUND Chronic Obstructive Pulmonary Disease (COPD) has emerged as a leading cause of mortality worldwide. Pulmonary Hypertension (PH) is a frequent complication associated with COPD and it is prevalent among 10% - 3...
CRYPTOCOCCAL MENINGITIS IN A DIAGNOSED AIDS PATIENT- A CASE REPORT
PRESENTATION OF CASE A forty three year old man with HIV infection was admitted in the medical ward of Government Medical College and Hospital, Nagpur with complaints of headache, fever (38.5° C) and neck rigidity for th...