Comparative Study for Methods of Extraction of Harmala Alkaloids
Journal Title: World Journal of Pharmaceutical Sciences - Year 2016, Vol 4, Issue 8
Abstract
Peganum harmala L. (Zygophyllaceae) is a wild flowering plant grows in Egypt and Mediterranean region. The seeds of this plant contain 2-5% Harman alkaloids which retain diverse pharmacological activity. Therefore, developing an efficient and economic method for extraction the alkaloids will pose a great importance for both medical and economical aspects. Microwave assisted extraction (MAE) and Ultrasonic assisted extraction (UAE) were used in comparison to the commonly used Soxhlet extraction method. MAE presented the highest yield of alkaloids (4.7 and 4.8%) after 15 and 30 minutes respectively. Meanwhile UAE produced 3.7 and 4.3% after 15 and 30 minutes respectively. However conventional Soxhlet extraction yielded 4.9 % after 7 hours of complete exhaustion extraction. This study revealed that MAE proved to be the most efficient and economic method of extraction for harmala alkaloids in comparison to other commonly used methods.
Authors and Affiliations
Prof. Farid A. Badria
Recombinant DNA technology in drug discovery
Recombinant DNA (rDNA) technology has made a revolutionary impact in the area of human healthcare by enabling mass production of safe, pure and effective rDNA expression products. Constructing a recombinant DNA molecule...
An introduction to Diabetic Neuropathy: A Review
Diabetic neuropathy is the most frequent and devastating complication of diabetes mellitus leading to great morbidity and mortality, resulting in a massive financial burden for diabetes care. The prevalence of diabetic n...
The Attenuation Effects of Apigenin, Vitexin, Hyperoside and Quercetin on Carrageenan-Induced Mice Tail Thrombosis Model
Flavonoids exert different pharmacological actions, such as analgesic, anti-inflammatory and cardioprotective activities Apigenin, vitexin, quercetin and hyperoside are flavonoids found within medicinal plants. We aimed...
A Study on Intrathecal Tramadol for prevention of shivering in Anorectal surgeries under Sub arachnoid anaesthesia
Shivering is very common problem during Sub arachnoid block (SAB), also known as Spinal anaesthesia. It can be prevented by intrathecal opioid injection. In our study we have included 50 patients scheduled for anorectal...
Flavocoxid Improves Bleomycin-Induced Respiratory Dysfunction and Pulmonary Fibrosis; In vitro Study
Pulmonary fibrosis; a progressive and fatal lung disorder is a common interstitial lung disease affecting millions of individuals worldwide with a mean survival time of about 3 years. It has been reported to be the most...