Comparative Study for Methods of Extraction of Harmala Alkaloids
Journal Title: World Journal of Pharmaceutical Sciences - Year 2016, Vol 4, Issue 8
Abstract
Peganum harmala L. (Zygophyllaceae) is a wild flowering plant grows in Egypt and Mediterranean region. The seeds of this plant contain 2-5% Harman alkaloids which retain diverse pharmacological activity. Therefore, developing an efficient and economic method for extraction the alkaloids will pose a great importance for both medical and economical aspects. Microwave assisted extraction (MAE) and Ultrasonic assisted extraction (UAE) were used in comparison to the commonly used Soxhlet extraction method. MAE presented the highest yield of alkaloids (4.7 and 4.8%) after 15 and 30 minutes respectively. Meanwhile UAE produced 3.7 and 4.3% after 15 and 30 minutes respectively. However conventional Soxhlet extraction yielded 4.9 % after 7 hours of complete exhaustion extraction. This study revealed that MAE proved to be the most efficient and economic method of extraction for harmala alkaloids in comparison to other commonly used methods.
Authors and Affiliations
Prof. Farid A. Badria
Effect of thyme (Thymus Vulgaris L.) oil on some biochemical parameters of diabetic female rats
The present study aimed to evaluate the influence of thyme oil on some biochemical parameters of diabetic female rats. Twenty four female rats divided into four groups each group contain six animals as following: the fir...
Antifungal activity and Nystatin Interaction with crude aqueous and Methanolic extracts of Azadirachta indica (Neem) on some fungal isolates
Antifungal activities of crude aqueous and methanolic extracts of Azadirachta indica on some fungal isolates were determined. Standard microbiological methods and methods in phamacognosy were used to determine phytochemi...
Quantitative analysis of α-glucosidase inhibitors by ECD with a column of the ion exchange resin of core-shell type filler
The α-glucosidase inhibitors, voglibose (VB), miglitol (MT), and acarbose (AB), are used as postprandial hyperglycemia inhibitors in the treatment of type 2 diabetes. The aim of this study was to develop a quantitative a...
Evaluation of drug use in the Urban Health Centre of tertiary health care using drug use indicators developed by WHO
The aim of the present study is to tackle ever increasing out of pocket health expenditure by the poor people, the Government of India has brought in National Health Mission with many strategies .One of the essential str...
Formulation development and in vitro evaluation of immediate release tablets of zolpidem tartrate
Zolpidem Tartarate belongs to class II drugs, that is, characterized by low solubility and high permeability therefore, the enhancement of its solubility and dissolution profile is expected to significantly improve its b...