Herb Preparations Improve the Viability of Hippocampal Cells Suppressed by Amyloid Beta (1-42) Peptide
Journal Title: World Journal of Pharmaceutical Sciences - Year 2017, Vol 5, Issue 6
Abstract
The aggregated amyloid peptides (Aβs) are considered as the hallmarks of Alzheimer's disease. We studied the ability of plant preparations, decreasing the aggregation state of amyloid peptides, to improve the viability of different type hippocampal cells, preliminarily suppressed by aggregated Aβ(1-42) peptide. The hippocampal cells were stained by antibodies against rabbit anti-rat Neurofilament (NF), glial fibrillary acidic protein (GFAP) and Nestin, which are specific for neuronal, glial and multipotent neural stem cells (NSCs), respectively. The aggregated Aβ(1-42) decreased in vitro the viability of all cell types down to <20 %. In the presence of phenol glycosides fraction from rose petals, ethanol extracts from sorrel leaves and melilot, the viability of GFAP- positive cells was restored up to ~170-150% of Aβ(1-42)-controls. The viability of Nestin-positive cells was restored by phenol glycosides fraction from rose petals and ethanol extract from sorrel leaves up to 210 and 230%, respectively, (p<0.05). Because the glial (GFAP-positive) and neural stem cells (Nestin-positive) can be reprogrammed into neurons, we can suggest sourcing therapeutics for neurodegeneration prevention and/or treatment from these plants.
Authors and Affiliations
Alvard Antonyan
Keywords
Related Articles
- EP ID EP330254
- DOI -
- Views 54
- Downloads 0
Protective Effect of Agaricus bisporus (Button mushroom) on Cisplatin Induced Nephrotoxicity in Albino Rats
The present study was carried out to investigate the nephroprotective effect of Agaricus bisporus extract on nephrotoxicity induced by cisplatin in male albino rats .Rats were randomly divided in to four groups. Group I...
Sjogren Syndrome: A Review on Diagnostic Methods and Treatment Strategies
Sjogren syndrome is a chronic autoimmune disease in which white blood cells attack and destroy moisture producing glands and causing reduced production of saliva (xerostomia) and tear (xerophthalmia). The treatment of sj...
The image of temple’s priestess in the poetry of “Silver Age”
The article regards images of priestesses of the temple in the works of Bryusov and Hlebnikov. As an example the poems of Bryusov “Aganat”. Phoenician story and “In the, Bela temple”, and Hlebnikov’s “Dark, black daughte...
Assessment of Clinical and Biomarker Response to Anti Tumour Necrosis Factor Alpha Biological in Spondyloarthritis using ASDAS CRP Criteria
Advanced laboratory techniques are playing an important role in the diagnosis of the disease which is a first and important step towards the treatment of the diseases. Spondyloarthritis (SpA) are a heterogeneous group of...
Correlation of the structural changes in OCT with functional visual field defects among Primary Open angle Glaucoma patients
Glaucoma is characterized by progressive degeneration of retinal ganglion cells and their axons that leads to nerve fiber layer loss, optic disc cupping, and consecutive glaucomatous visual field changes. Study is done i...